EC 1 - Oxidoreductases
EC 1.2 - Acting on the aldehyde or oxo group of donors
EC 1.2.1 - With NAD+ or NADP+ as acceptor
EC 1.2.1.94 - Farnesal dehydrogenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.2.1.94
Names
Accepted name:
farnesal dehydrogenase
Other
name:
AaALDH3
Systematic name:
farnesal:NAD+ oxidoreductase
Reaction
-
24216 [IUBMB](2E,6E)-farnesalName origin: UniProt - CHECKED (C)Formula: C15H24O
Charge: 0ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)NAD+Name origin: UniProt - CHECKED (C)Formula: C21H26N7O14P2
Charge: -1ChEBI compound status: CHECKED (C)=(2E,6E)-farnesoateName origin: UniProt - CHECKED (C)Formula: C15H23O2
Charge: -1ChEBI compound status: CHECKED (C)2H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)
Comments:
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito).
Links to other databases
UniProtKB/Swiss-Prot:
AL3A2-2_HUMAN
AL3A2_HUMAN
AL3A2_MACFA
AL3A2_MOUSE
AL3A2_PONAB
AL3A2_RAT
References
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Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase.J. Insect Physiol. 19 : 235-241 (1973). [PMID: 4631837]
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Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta.J. Lipid Res. 24 : 1586-1594 (1983). [PMID: 6366103]
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Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes.Insect Biochem. Mol. Biol. 43 : 675-682 (2013). [PMID: 23639754]
[EC 1.2.1.94 created 2015]