IntEnz

EC 1.2.1.94 - Farnesal dehydrogenase

IntEnz Enzyme Nomenclature
EC 1.2.1.94

Names

Reaction

• 24216 [IUBMB]
  (2E,6E)-farnesal

  (2E,6E)-farnesal

  Name origin: UniProt - CHECKED (C)

  CHEBI:15894

  Formula: C15H24O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  (2E,6E)-farnesoate

  (2E,6E)-farnesoate

  Name origin: UniProt - CHECKED (C)

  CHEBI:83276

  Formula: C15H23O2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito).

Links to other databases

References

1. Madhavan, K., Conscience-Egli, M., Sieber, F., Ursprung, H.
   Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase.
   J. Insect Physiol. 19: 235-241 (1973). [PMID: 4631837]
2. Baker, F. C., Mauchamp, B., Tsai, L. W., Schooley, D. A.
   Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta.
   J. Lipid Res. 24: 1586-1594 (1983). [PMID: 6366103]
3. Rivera-Perez, C., Nouzova, M., Clifton, M. E., Garcia, E. M., LeBlanc, E., Noriega, F. G.
   Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes.
   Insect Biochem. Mol. Biol. 43: 675-682 (2013). [PMID: 23639754]

[EC 1.2.1.94 created 2015]