EC 1 - Oxidoreductases
EC 1.2 - Acting on the aldehyde or oxo group of donors
EC 1.2.1 - With NAD+ or NADP+ as acceptor
EC 1.2.1.79 - Succinate-semialdehyde dehydrogenase (NADP+)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.2.1.79
Names
Accepted name:
succinate-semialdehyde dehydrogenase (NADP+)
Other
names:
succinic semialdehyde dehydrogenase (NADP+)
succinyl semialdehyde dehydrogenase (NADP+)
succinate semialdehyde:NADP+ oxidoreductase
NADP-dependent succinate-semialdehyde dehydrogenase
GabD
succinyl semialdehyde dehydrogenase (NADP+)
succinate semialdehyde:NADP+ oxidoreductase
NADP-dependent succinate-semialdehyde dehydrogenase
GabD
Systematic name:
succinate-semialdehyde:NADP+ oxidoreductase
Reaction
- succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+
Comments:
This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. The enzyme from Escherichia coli is 20-fold more active with NADP+ than NAD+ [2].
Links to other databases
Gene Ontology:
GO:0036243
References
-
Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD).J. Bacteriol. 172 : 7035-7042 (1990). [PMID: 2254272]
-
Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases.Biochem. Biophys. Res. Commun. 372 : 400-406 (2008). [PMID: 18474219]
[EC 1.2.1.79 created 2010]