IntEnz

EC 1.2.1.79 - Succinate-semialdehyde dehydrogenase (NADP⁺)

IntEnz Enzyme Nomenclature
EC 1.2.1.79

Names

Reaction

• 13213 [IUBMB]
  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NADP⁺

  NADP(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:58349

  Formula: C21H25N7O17P3
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  succinate semialdehyde

  succinate semialdehyde

  Name origin: UniProt - CHECKED (C)

  CHEBI:57706

  Formula: C4H5O3
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADPH

  NADPH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57783

  Formula: C21H26N7O17P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  succinate

  succinate

  Name origin: UniProt - CHECKED (C)

  CHEBI:30031

  Formula: C4H4O4
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD⁺)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)⁺)], but is specific for NADP⁺. The enzyme from Escherichia coli is 20-fold more active with NADP⁺ than NAD⁺ [2].

Links to other databases

References

1. Bartsch, K., von Johnn-Marteville, A., Schulz, A.
   Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD).
   J. Bacteriol. 172: 7035-7042 (1990). [PMID: 2254272]
2. Jaeger, M., Rothacker, B., Ilg, T.
   Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases.
   Biochem. Biophys. Res. Commun. 372: 400-406 (2008). [PMID: 18474219]

[EC 1.2.1.79 created 2010]