EC 1.2.1.79 - Succinate-semialdehyde dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature
EC 1.2.1.79

Names

Accepted name:
succinate-semialdehyde dehydrogenase (NADP+)
Other names:
succinic semialdehyde dehydrogenase (NADP+)
succinyl semialdehyde dehydrogenase (NADP+)
succinate semialdehyde:NADP+ oxidoreductase
NADP-dependent succinate-semialdehyde dehydrogenase
GabD
Systematic name:
succinate-semialdehyde:NADP+ oxidoreductase

Reaction

Comments:

This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. The enzyme from Escherichia coli is 20-fold more active with NADP+ than NAD+ [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036243
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Bartsch, K., von Johnn-Marteville, A., Schulz, A.
    Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD).
    J. Bacteriol. 172 : 7035-7042 (1990). [PMID: 2254272]
  2. Jaeger, M., Rothacker, B., Ilg, T.
    Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases.
    Biochem. Biophys. Res. Commun. 372 : 400-406 (2008). [PMID: 18474219]

[EC 1.2.1.79 created 2010]