EC - Succinylglutamate-semialdehyde dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
succinylglutamate-semialdehyde dehydrogenase
Other names:
succinylglutamic semialdehyde dehydrogenase
N-succinylglutamate 5-semialdehyde dehydrogenase
Systematic name:
N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase



This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC (arginine N-succinyltransferase), EC (N-succinylarginine dihydrolase), EC (acetylornithine transaminase), EC (succinylglutamate-semialdehyde dehydrogenase) and EC (succinylglutamate desuccinylase) [3,6].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00068
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043824
UniProtKB/Swiss-Prot: (134) [show] [UniProt]


  1. Vander Wauven, C., Jann, A., Haas, D., Leisinger, T. and Stalon, V.
    N2-succinylornithine in ornithine catabolism of Pseudomonas aeruginosa.
    Arch. Microbiol. 150 : 400-404 (1988). [PMID: 3144259]
  2. Vander Wauven, C. and Stalon, V.
    Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia.
    J. Bacteriol. 164 : 882-886 (1985). [PMID: 2865249]
  3. Tricot, C., Vander Wauven, C., Wattiez, R., Falmagne, P. and Stalon, V.
    Purification and properties of a succinyltransferase from Pseudomonas aeruginosa specific for both arginine and ornithine.
    Eur. J. Biochem. 224 : 853-861 (1994). [PMID: 7523119]
  4. Itoh, Y.
    Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.
    J. Bacteriol. 179 : 7280-7290 (1997). [PMID: 9393691]
  5. Schneider, B.L., Kiupakis, A.K. and Reitzer, L.J.
    Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.
    J. Bacteriol. 180 : 4278-4286 (1998). [PMID: 9696779]
  6. Cunin, R., Glansdorff, N., Piérard, A. and Stalon, V.
    Biosynthesis and metabolism of arginine in bacteria.
    Microbiol. Rev. 50 : 314-352 (1986). [PMID: 3534538]
  7. Cunin, R., Glansdorff, N., Piérard, A. and Stalon, V.
    Erratum report. Biosynthesis and metabolism of arginine in bacteria.
    Microbiol. Rev. 51 : 178 (1987).

[EC created 2006]