EC 1 - Oxidoreductases
EC 1.2 - Acting on the aldehyde or oxo group of donors
EC 1.2.1 - With NAD+ or NADP+ as acceptor
EC 1.2.1.70 - Glutamyl-tRNA reductase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.2.1.70
Names
Accepted name:
glutamyl-tRNA reductase
Systematic name:
L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)
Reaction
- L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+
Comments:
This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway, which is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the α-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic α-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00608
Gene Ontology:
GO:0008883
HEM11_ANADE
HEM11_ANADF
HEM11_ARATH
HEM11_CUCSA
HEM11_FLAJ1
HEM11_HORVU
HEM11_KORVE
HEM11_LACP7
HEM11_NOCSJ
HEM11_PYRAR
HEM11_PYRCJ
HEM12_ANADE
HEM12_ANADF
HEM12_ARATH
HEM12_CUCSA
HEM12_FLAJ1
HEM12_HORVU
HEM12_KORVE
HEM12_LACP7
HEM12_NOCSJ
HEM12_PYRAR
HEM12_PYRCJ
HEM13_ARATH
HEM13_HORVU
HEM1_ACAM1
HEM1_ACET2
HEM1_ACIAC
HEM1_ACIAD
HEM1_ACIB3
HEM1_ACIB5
HEM1_ACIBC
HEM1_ACIBS
HEM1_ACIBT
HEM1_ACIBY
HEM1_ACIC1
HEM1_ACISJ
HEM1_ACTP2
HEM1_ACTP7
HEM1_ACTPJ
HEM1_ACTSZ
HEM1_AERHH
HEM1_AERPE
HEM1_AERS4
HEM1_AKKM8
HEM1_ALCBS
HEM1_ALIB4
HEM1_ALIF1
HEM1_ALIFM
HEM1_ALISL
HEM1_ALKEH
HEM1_ALKHC
HEM1_ALKMQ
HEM1_ALKOO
HEM1_AQUAE
HEM1_ARCFU
HEM1_AROAE
HEM1_ARTS2
HEM1_AZOSB
HEM1_BACAA
HEM1_BACAC
HEM1_BACAH
HEM1_BACAN
HEM1_BACC0
HEM1_BACC1
HEM1_BACC2
HEM1_BACC3
HEM1_BACC4
HEM1_BACC7
HEM1_BACCN
HEM1_BACCQ
HEM1_BACCR
HEM1_BACCZ
HEM1_BACHK
HEM1_BACLD
HEM1_BACMK
HEM1_BACP2
HEM1_BACSK
HEM1_BACSU
HEM1_BACVZ
HEM1_BEUC1
HEM1_BORA1
HEM1_BORBR
HEM1_BORPA
HEM1_BORPE
HEM1_BREBN
HEM1_BURA4
HEM1_BURCA
HEM1_BURCC
HEM1_BURCH
HEM1_BURCJ
HEM1_BURCM
HEM1_BURL3
HEM1_BURM1
HEM1_BURM7
HEM1_BURM9
HEM1_BURMA
HEM1_BURMS
HEM1_BURP0
HEM1_BURP1
HEM1_BURP6
HEM1_BURPS
HEM1_BURTA
HEM1_BURVG
HEM1_CALBD
HEM1_CALMQ
HEM1_CALS8
HEM1_CAMC1
HEM1_CAMC5
HEM1_CAMFF
HEM1_CAMHC
HEM1_CAMJ8
HEM1_CAMJD
HEM1_CAMJE
HEM1_CAMJJ
HEM1_CAMJR
HEM1_CAMLR
HEM1_CARHZ
HEM1_CENSY
HEM1_CHLAA
HEM1_CHLAB
HEM1_CHLAD
HEM1_CHLCH
HEM1_CHLCV
HEM1_CHLFF
HEM1_CHLL2
HEM1_CHLL3
HEM1_CHLMU
HEM1_CHLP8
HEM1_CHLPB
HEM1_CHLPD
HEM1_CHLPM
HEM1_CHLPN
HEM1_CHLSY
HEM1_CHLT2
HEM1_CHLT3
HEM1_CHLTA
HEM1_CHLTB
HEM1_CHLTE
HEM1_CHLTR
HEM1_CHRSD
HEM1_CHRVO
HEM1_CITBB
HEM1_CITK8
HEM1_CLAM3
HEM1_CLAMS
HEM1_CLOAB
HEM1_CLOB8
HEM1_CLOBA
HEM1_CLOBB
HEM1_CLOK1
HEM1_CLOK5
HEM1_CLONN
HEM1_CLOP1
HEM1_CLOPE
HEM1_CLOPS
HEM1_CLOTE
HEM1_COLP3
HEM1_CORA7
HEM1_CORDI
HEM1_COREF
HEM1_CORGB
HEM1_CORGL
HEM1_CORJK
HEM1_CORU7
HEM1_COXBN
HEM1_COXBR
HEM1_COXBU
HEM1_CROS5
HEM1_CROS8
HEM1_CUPMC
HEM1_CUPNH
HEM1_CUPPJ
HEM1_CUTAK
HEM1_CYAP4
HEM1_CYAPA
HEM1_CYTH3
HEM1_DECAR
HEM1_DEIGD
HEM1_DEIRA
HEM1_DESAG
HEM1_DESAL
HEM1_DESAP
HEM1_DESDA
HEM1_DESHD
HEM1_DESHY
HEM1_DESMR
HEM1_DESPS
HEM1_DESRM
HEM1_DESVH
HEM1_DESVM
HEM1_DESVV
HEM1_DICNV
HEM1_ECO24
HEM1_ECO27
HEM1_ECO45
HEM1_ECO55
HEM1_ECO57
HEM1_ECO5E
HEM1_ECO7I
HEM1_ECO81
HEM1_ECO8A
HEM1_ECOBW
HEM1_ECODH
HEM1_ECOHS
HEM1_ECOK1
HEM1_ECOL5
HEM1_ECOL6
HEM1_ECOLC
HEM1_ECOLI
HEM1_ECOLU
HEM1_ECOSE
HEM1_ECOSM
HEM1_ECOUT
HEM1_EDWI9
HEM1_ENT38
HEM1_ERWT9
HEM1_ESCF3
HEM1_EXIS2
HEM1_EXISA
HEM1_FLAPJ
HEM1_FRAAA
HEM1_FRACC
HEM1_FRAP2
HEM1_FRASN
HEM1_FRAT1
HEM1_FRATF
HEM1_FRATH
HEM1_FRATM
HEM1_FRATN
HEM1_FRATO
HEM1_FRATT
HEM1_FRATW
HEM1_FUSNN
HEM1_GEODF
HEM1_GEOKA
HEM1_GEOLS
HEM1_GEOMG
HEM1_GEOSL
HEM1_GEOSM
HEM1_GEOTN
HEM1_GEOUR
HEM1_GLOC7
HEM1_GLOVI
HEM1_GRAFK
HEM1_HAEPS
HEM1_HAES1
HEM1_HAHCH
HEM1_HALHL
HEM1_HALMA
HEM1_HALS3
HEM1_HALSA
HEM1_HALWD
HEM1_HELAH
HEM1_HELHP
HEM1_HELMO
HEM1_HELP2
HEM1_HELPG
HEM1_HELPH
HEM1_HELPJ
HEM1_HELPS
HEM1_HELPY
HEM1_HERA2
HEM1_HERAR
HEM1_HISS2
HEM1_HYDCU
HEM1_HYPBU
HEM1_IDILO
HEM1_IGNH4
HEM1_JANMA
HEM1_KINRD
HEM1_KLEP3
HEM1_KLEP7
HEM1_KOCRD
HEM1_LAWIP
HEM1_LEGPA
HEM1_LEGPC
HEM1_LEGPH
HEM1_LEGPL
HEM1_LEIXX
HEM1_LIMRD
HEM1_LIMRJ
HEM1_LISIN
HEM1_LISMC
HEM1_LISMF
HEM1_LISMH
HEM1_LISMO
HEM1_LISW6
HEM1_LYSSC
HEM1_MACCJ
HEM1_MAGMM
HEM1_MANSM
HEM1_MARMS
HEM1_MARN8
HEM1_MARSD
HEM1_META3
HEM1_METAC
HEM1_METAR
HEM1_METB6
HEM1_METBF
HEM1_METBU
HEM1_METCA
HEM1_METFK
HEM1_METHJ
HEM1_METJA
HEM1_METKA
HEM1_METLZ
HEM1_METM5
HEM1_METM6
HEM1_METM7
HEM1_METMA
HEM1_METMJ
HEM1_METMP
HEM1_METPP
HEM1_METS3
HEM1_METS5
HEM1_METST
HEM1_METTH
HEM1_METTM
HEM1_METTP
HEM1_METVS
HEM1_MICAN
HEM1_MICLC
HEM1_MOOTA
HEM1_MYCA1
HEM1_MYCA9
HEM1_MYCBO
HEM1_MYCBP
HEM1_MYCBT
HEM1_MYCGI
HEM1_MYCLE
HEM1_MYCPA
HEM1_MYCS2
HEM1_MYCSJ
HEM1_MYCSK
HEM1_MYCSS
HEM1_MYCTA
HEM1_MYCTO
HEM1_MYCTU
HEM1_MYCUA
HEM1_MYCVP
HEM1_MYXXD
HEM1_NATPD
HEM1_NATTJ
HEM1_NEIG1
HEM1_NEIG2
HEM1_NEIM0
HEM1_NEIMA
HEM1_NEIMB
HEM1_NEIMC
HEM1_NEIMF
HEM1_NITEC
HEM1_NITEU
HEM1_NITMU
HEM1_NITOC
HEM1_NITSB
HEM1_NOCFA
HEM1_NOSP7
HEM1_NOSS1
HEM1_OCEIH
HEM1_ORYSI
HEM1_ORYSJ
HEM1_PAEAT
HEM1_PAEMA
HEM1_PARMW
HEM1_PARP8
HEM1_PARPJ
HEM1_PARUW
HEM1_PARXL
HEM1_PASMU
HEM1_PECAS
HEM1_PECCP
HEM1_PELPB
HEM1_PELPD
HEM1_PELTS
HEM1_PERMH
HEM1_PHOLL
HEM1_PHOPR
HEM1_PICTO
HEM1_POLAQ
HEM1_POLNA
HEM1_POLSJ
HEM1_PRIMG
HEM1_PROA2
HEM1_PROM0
HEM1_PROM1
HEM1_PROM2
HEM1_PROM3
HEM1_PROM4
HEM1_PROM5
HEM1_PROM9
HEM1_PROMA
HEM1_PROMH
HEM1_PROMM
HEM1_PROMP
HEM1_PROMS
HEM1_PROMT
HEM1_PSE14
HEM1_PSEA6
HEM1_PSEA7
HEM1_PSEA8
HEM1_PSEAB
HEM1_PSEAE
HEM1_PSECP
HEM1_PSEE4
HEM1_PSEF5
HEM1_PSEFS
HEM1_PSEMY
HEM1_PSEP1
HEM1_PSEPF
HEM1_PSEPG
HEM1_PSEPK
HEM1_PSEPW
HEM1_PSESM
HEM1_PSET1
HEM1_PSEU2
HEM1_PSEU5
HEM1_PSYA2
HEM1_PSYCK
HEM1_PSYIN
HEM1_PSYWF
HEM1_PYRAE
HEM1_PYRIL
HEM1_PYRNV
HEM1_RALSO
HEM1_RENSM
HEM1_RHOBA
HEM1_RHOE4
HEM1_RHOFT
HEM1_RHOJR
HEM1_RHOOB
HEM1_RHORT
HEM1_RIPO1
HEM1_ROSCS
HEM1_ROSS1
HEM1_RUBXD
HEM1_RUTMC
HEM1_SACD2
HEM1_SACEN
HEM1_SACS2
HEM1_SALA4
HEM1_SALAI
HEM1_SALAR
HEM1_SALCH
HEM1_SALDC
HEM1_SALEP
HEM1_SALG2
HEM1_SALHS
HEM1_SALNS
HEM1_SALPA
HEM1_SALPB
HEM1_SALPK
HEM1_SALRD
HEM1_SALSV
HEM1_SALTI
HEM1_SALTO
HEM1_SALTY
HEM1_SERP5
HEM1_SHEAM
HEM1_SHEB2
HEM1_SHEB5
HEM1_SHEB8
HEM1_SHEB9
HEM1_SHEDO
HEM1_SHEFN
HEM1_SHEHH
HEM1_SHELP
HEM1_SHEON
HEM1_SHEPA
HEM1_SHEPC
HEM1_SHEPW
HEM1_SHESA
HEM1_SHESH
HEM1_SHESM
HEM1_SHESR
HEM1_SHESW
HEM1_SHEWM
HEM1_SHIB3
HEM1_SHIBS
HEM1_SHIDS
HEM1_SHIF8
HEM1_SHIFL
HEM1_SHISS
HEM1_SODGM
HEM1_SOLUE
HEM1_SORC5
HEM1_STAA1
HEM1_STAA2
HEM1_STAA3
HEM1_STAA8
HEM1_STAA9
HEM1_STAAB
HEM1_STAAC
HEM1_STAAE
HEM1_STAAM
HEM1_STAAN
HEM1_STAAR
HEM1_STAAS
HEM1_STAAT
HEM1_STAAW
HEM1_STACT
HEM1_STAEQ
HEM1_STAES
HEM1_STAHJ
HEM1_STAS1
HEM1_STRAW
HEM1_STRCO
HEM1_STRM5
HEM1_STRMK
HEM1_STRSV
HEM1_SULAC
HEM1_SULDN
HEM1_SULIA
HEM1_SULIK
HEM1_SULIL
HEM1_SULIM
HEM1_SULIN
HEM1_SULIY
HEM1_SULNB
HEM1_SULSY
HEM1_SULTO
HEM1_SYNAS
HEM1_SYNC1
HEM1_SYNE7
HEM1_SYNFM
HEM1_SYNJA
HEM1_SYNJB
HEM1_SYNP2
HEM1_SYNP6
HEM1_SYNPW
HEM1_SYNR3
HEM1_SYNS3
HEM1_SYNS9
HEM1_SYNSC
HEM1_SYNY3
HEM1_TERTT
HEM1_THEAC
HEM1_THEFY
HEM1_THEM4
HEM1_THERP
HEM1_THET2
HEM1_THET8
HEM1_THEVB
HEM1_THEVO
HEM1_THEYD
HEM1_THIDA
HEM1_TRIEI
HEM1_TRIV2
HEM1_TROW8
HEM1_TROWT
HEM1_VEREI
HEM1_VESOH
HEM1_VIBA3
HEM1_VIBC3
HEM1_VIBCB
HEM1_VIBCH
HEM1_VIBCM
HEM1_VIBPA
HEM1_VIBVU
HEM1_VIBVY
HEM1_WIGBR
HEM1_WOLSU
HEM1_XANAC
HEM1_XANC5
HEM1_XANC8
HEM1_XANCB
HEM1_XANCH
HEM1_XANCP
HEM1_XANOM
HEM1_XANOP
HEM1_XANOR
HEM1_XYLF2
HEM1_XYLFA
HEM1_XYLFM
HEM1_XYLFT
HEM1_YERE8
HEM1_YERP3
HEM1_YERPA
HEM1_YERPE
HEM1_YERPG
HEM1_YERPN
HEM1_YERPP
HEM1_YERPS
HEMA_RUMJO
References
-
Von Wettstein, D., Gough, S. and Kannangara, C.G.Chlorophyll biosynthesis.Plant Cell 7 : 1039-1057 (1995). [PMID: 12242396]
-
Pontoppidan, B. Kannangara, C.G.Purification and partial characterisation of barley glutamyl-tRNAGlu reductase, the enzyme that directs glutamate to chlorophyll biosynthesis.Eur. J. Biochem. 225 : 529-537 (1994). [PMID: 7957167]
-
Schauer, S., Chaturvedi, S., Randau, L., Moser, J., Kitabatake, M., Lorenz, S., Verkamp, E., Schubert, W.D., Nakayashiki, T., Murai, M., Wall, K., Thomann, H.-U., Heinz, D.W., Inokuchi, H., Söll, D. and Jahn, D.Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate.J. Biol. Chem. 277 : 48657-48663 (2002). [PMID: 12370189]
[EC 1.2.1.70 created 2004]