Read more about EC 1.2.1.70 ...
EC 1.2.1.70 - Glutamyl-tRNA reductase

  IntEnz view ENZYME view
XML

IntEnz Enzyme Nomenclature
EC 1.2.1.70

Names

Accepted name:
glutamyl-tRNA reductase
Systematic name:
L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)

Reaction

Comments:

This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway, which is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the α-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic α-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00608
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008883
UniProtKB/Swiss-Prot: (583) [show] [UniProt]

References

  1. Von Wettstein, D., Gough, S. and Kannangara, C.G.
    Chlorophyll biosynthesis.
    Plant Cell 7: 1039-1057 (1995). [PMID: 12242396]
  2. Pontoppidan, B. Kannangara, C.G.
    Purification and partial characterisation of barley glutamyl-tRNAGlu reductase, the enzyme that directs glutamate to chlorophyll biosynthesis.
    Eur. J. Biochem. 225: 529-537 (1994). [PMID: 7957167]
  3. Schauer, S., Chaturvedi, S., Randau, L., Moser, J., Kitabatake, M., Lorenz, S., Verkamp, E., Schubert, W.D., Nakayashiki, T., Murai, M., Wall, K., Thomann, H.-U., Heinz, D.W., Inokuchi, H., Söll, D. and Jahn, D.
    Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate.
    J. Biol. Chem. 277: 48657-48663 (2002). [PMID: 12370189]

[EC 1.2.1.70 created 2004]