EC - 4-hydroxybenzaldehyde dehydrogenase (NAD+)

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxybenzaldehyde dehydrogenase (NAD+)
Other names:
p-hydroxybenzaldehyde dehydrogenase [ambiguous]
4-hydroxybenzaldehyde dehydrogenase [ambiguous]
Systematic name:
4-hydroxybenzaldehyde:NAD+ oxidoreductase



The bacterial enzyme (characterized from an unidentified denitrifying bacterium) is involved in an anaerobic toluene degradation pathway. The plant enzyme is involved in formation of 4-hydroxybenzoate, a cell wall-bound phenolic acid that plays a major role in plant defense against pathogens. cf. EC, 4-hydroxybenzaldehyde dehydrogenase (NADP+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018484


  1. Bossert, I.D., Whited, G., Gibson, D.T. and Young, L.Y.
    Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium.
    J. Bacteriol. 171 : 2956-2962 (1989). [PMID: 2722739]
  2. Sircar, D., Mitra, A.
    Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota.
    J. Plant Physiol. 165 : 407-414 (2008). [PMID: 17658659]

[EC created 2000, modified 2015]