IntEnz

EC 1.2.1.60 - 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase

IntEnz Enzyme Nomenclature
EC 1.2.1.60

Names

Reaction

• 15681 [IUBMB]
  2-hydroxy-5-carboxymethylmuconate semialdehyde

  2-hydroxy-5-carboxymethylmuconate semialdehyde

  Name origin: UniProt - CHECKED (C)

  CHEBI:58030

  Formula: C8H6O6
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate

  (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate

  Name origin: UniProt - CHECKED (C)

  CHEBI:47961

  Formula: C8H5O7
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

Involved in the tyrosine degradation pathway in Arthrobacter sp.

Links to other databases

References

1. Blakley, E.R.
   The catabolism of L-tyrosine by an Arthrobacter sp.
   Can. J. Microbiol. 23: 1128-1139 (1977). [PMID: 20216]
2. Alonso, J.M. and Garrido-Pertierra, A.
   Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
   Biochim. Biophys. Acta 719: 165-167 (1982). [PMID: 6756482]
3. Cooper, R.A. and Skinner, M.A.
   Catabolism of 3- and 4-hydroxyphenylacetate by the3,4-dihydroxyphenylacetate pathway in Escherichia coli.
   J. Bacteriol. 143: 302-306 (1980). [PMID: 6995433]
4. Garrido-Pertierra, A. and Cooper, R.A.
   Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate pathway of Escherichia coli.
   Eur. J. Biochem. 117: 581-584 (1981).

[EC 1.2.1.60 created 2000]