EC - 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
Other name:
carboxymethylhydroxymuconic semialdehyde dehydrogenase
Systematic name:
5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase



Involved in the tyrosine degradation pathway in Arthrobacter sp.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018480


  1. Blakley, E.R.
    The catabolism of L-tyrosine by an Arthrobacter sp.
    Can. J. Microbiol. 23 : 1128-1139 (1977). [PMID: 20216]
  2. Alonso, J.M. and Garrido-Pertierra, A.
    Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
    Biochim. Biophys. Acta 719 : 165-167 (1982). [PMID: 6756482]
  3. Cooper, R.A. and Skinner, M.A.
    Catabolism of 3- and 4-hydroxyphenylacetate by the3,4-dihydroxyphenylacetate pathway in Escherichia coli.
    J. Bacteriol. 143 : 302-306 (1980). [PMID: 6995433]
  4. Garrido-Pertierra, A. and Cooper, R.A.
    Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate pathway of Escherichia coli.
    Eur. J. Biochem. 117 : 581-584 (1981).

[EC created 2000]