IntEnz - EC 1.2.1.53

EC 1 - Oxidoreductases

EC 1.2 - Acting on the aldehyde or oxo group of donors

EC 1.2.1 - With NAD⁺ or NADP⁺ as acceptor

EC 1.2.1.53 - 4-hydroxyphenylacetaldehyde dehydrogenase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.2.1.53

Names

Accepted name:

4-hydroxyphenylacetaldehyde dehydrogenase

Other name:

4-HPAL dehydrogenase

Systematic name:

4-hydroxyphenylacetaldehyde:NAD⁺ oxidoreductase

Reaction

17273 [IUBMB]

(4-hydroxyphenyl)acetaldehyde

(4-hydroxyphenyl)acetaldehyde

Name origin: UniProt - CHECKED (C)

CHEBI:15621

Formula: C8H8O2
Charge: 0

ChEBI compound status: CHECKED (C)

+

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

+

NAD⁺

NAD(+)

Name origin: UniProt - CHECKED (C)

CHEBI:57540

Formula: C21H26N7O14P2
Charge: -1

ChEBI compound status: CHECKED (C)

=

4-hydroxyphenylacetate

4-hydroxyphenylacetate

Name origin: UniProt - CHECKED (C)

CHEBI:48999

Formula: C8H7O3
Charge: -1

ChEBI compound status: CHECKED (C)

+
2

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

NADH

NADH

Name origin: UniProt - CHECKED (C)

CHEBI:57945

Formula: C21H27N7O14P2
Charge: -2

ChEBI compound status: CHECKED (C)

Comments:

With EC 4.2.1.87 octopamine dehydratase, brings about the metabolism of octopamine in Pseudomonas..

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0047106

CAS Registry Number: 109456-56-6

References

Cuskey, S.M., Peccoraro, V. and Olsen, R.H.

Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes.

J. Bacteriol. 169: 2398-2404 (1987). [PMID: 3034855]

[EC 1.2.1.53 created 1989]