EC - Pyruvate dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
pyruvate dehydrogenase (NADP+)
Systematic name:
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)



The Euglena enzyme can also use FAD or methylviologen as acceptor, more slowly. The enzyme is inhibited by oxygen.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050243
CAS Registry Number: 93389-35-6


  1. Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S.
    Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis.
    J. Biochem. (Tokyo) 96 : 931-934 (1984). [PMID: 6438078]
  2. Inui, H., Ono, K., Miyatake, K., Nakano, Y. and Kitaoka, S.
    Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis.
    J. Biol. Chem. 262 : 9130-9135 (1987). [PMID: 3110154]

[EC created 1989]