EC - 2-oxoaldehyde dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
2-oxoaldehyde dehydrogenase (NADP+)
Other names:
2-ketoaldehyde dehydrogenase
α-ketoaldehyde dehydrogenase
NADP-dependent α-ketoaldehyde dehydrogenase
NADP-linked α-ketoaldehyde dehydrogenase
methylglyoxal dehydrogenase
Systematic name:
2-oxoaldehyde:NADP+ 2-oxidoreductase



Not identical with EC 2-oxoaldehyde dehydrogenase (NAD+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047552
CAS Registry Numbers: 83588-97-0 97162-76-0


  1. Ray, M. and Ray, S.
    On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase.
    J. Biol. Chem. 257 : 10571-10574 (1982). [PMID: 7107626]
  2. Ray, S. and Ray, M.
    Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate.
    J. Biol. Chem. 257 : 10566-10570 (1982). [PMID: 7107625]

[EC created 1986]