IntEnz

EC 1.2.1.49 - 2-oxoaldehyde dehydrogenase (NADP⁺)

IntEnz Enzyme Nomenclature
EC 1.2.1.49

Names

Reaction

• 18129 [IUBMB]
  2-oxoaldehyde

  2-oxoaldehyde

  Name origin: UniProt - CHECKED (C)

  CHEBI:27659

  Formula: C2HO2R
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NADP⁺

  NADP(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:58349

  Formula: C21H25N7O17P3
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  =

  a 2-oxocarboxylate

  a 2-oxocarboxylate

  Name origin: UniProt - CHECKED (C)

  CHEBI:35179

  Formula: C2O3R
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADPH

  NADPH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57783

  Formula: C21H26N7O17P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

Comments:

Not identical with EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD⁺).

Links to other databases

References

1. Ray, M. and Ray, S.
   On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase.
   J. Biol. Chem. 257: 10571-10574 (1982). [PMID: 7107626]
2. Ray, S. and Ray, M.
   Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate.
   J. Biol. Chem. 257: 10566-10570 (1982). [PMID: 7107625]

[EC 1.2.1.49 created 1986]