IntEnz - EC 1.2.1.41

EC 1 - Oxidoreductases

EC 1.2 - Acting on the aldehyde or oxo group of donors

EC 1.2.1 - With NAD⁺ or NADP⁺ as acceptor

EC 1.2.1.41 - Glutamate-5-semialdehyde dehydrogenase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.2.1.41

Names

Accepted name:

glutamate-5-semialdehyde dehydrogenase

Other names:

β-glutamylphosphate reductase
γ-glutamyl phosphate reductase
glutamate semialdehyde dehydrogenase
glutamate-γ-semialdehyde dehydrogenase

Systematic name:

L-glutamate-5-semialdehyde:NADP⁺ 5-oxidoreductase (phosphorylating)

Reaction

19541 [IUBMB]

L-glutamate 5-semialdehyde

L-glutamate 5-semialdehyde

Name origin: UniProt - CHECKED (C)

CHEBI:58066

Formula: C5H9NO3
Charge: 0

ChEBI compound status: CHECKED (C)

+

NADP⁺

NADP(+)

Name origin: UniProt - CHECKED (C)

CHEBI:58349

Formula: C21H25N7O17P3
Charge: -3

ChEBI compound status: CHECKED (C)

+

phosphate

phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:43474

Formula: HO4P
Charge: -2

ChEBI compound status: CHECKED (C)

=

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

L-glutamyl 5-phosphate

L-glutamyl 5-phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:58274

Formula: C5H8NO7P
Charge: -2

ChEBI compound status: CHECKED (C)

+

NADPH

NADPH

Name origin: UniProt - CHECKED (C)

CHEBI:57783

Formula: C21H26N7O17P3
Charge: -4

ChEBI compound status: CHECKED (C)

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Protein domains and families: PROSITE:PDOC00940

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004350

CAS Registry Number: 54596-29-1

UniProtKB/Swiss-Prot: (578) [show] [UniProt]

References

Baich, A.

The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway.

Biochim. Biophys. Acta 244: 129-134 (1971). [PMID: 4399189]

[EC 1.2.1.41 created 1976]