EC - L-aminoadipate-semialdehyde dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
L-aminoadipate-semialdehyde dehydrogenase
Other names:
2-aminoadipate semialdehyde dehydrogenase
2-aminoadipic semialdehyde dehydrogenase
α-aminoadipate reductase
α-aminoadipate-semialdehyde dehydrogenase
L-α-aminoadipate δ-semialdehyde oxidoreductase
L-α-aminoadipate δ-semialdehyde:NAD oxidoreductase
L-α-aminoadipate δ-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase
aminoadipate semialdehyde dehydrogenase
L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
Systematic name:
(S)-2-amino-6-oxohexanoate:NAD(P)+ 6-oxidoreductase



(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00427
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004043
CAS Registry Number: 9067-87-2
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Calvert, A.F. and Rodwell, V.W.
    Metabolism of pipecolic acid in a Pseudomonas species. 3. L-α-Aminoadipate δ-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase.
    J. Biol. Chem. 241 : 409-414 (1966). [PMID: 4285660]
  2. Rodwell, V.W.
    Δ1-piperideine-6-carboxylic acid and alpha-aminoadipic acid delta-semialdehyde.
    Method Enzymol. 17B : 188-199 (1971).
  3. de La Fuente, J. L., Rumbero, A., Martin, J. F., Liras, P.
    Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.
    Biochem. J. 327 : 59-64 (1997). [PMID: 9355735]
  4. Fujii, T., Narita, T., Agematu, H., Agata, N., Isshiki, K.
    Cloning and characterization of pcd encoding delta'-piperideine-6-carboxylate dehydrogenase from flavobacterium lutescens IFO3084.
    J. Biochem. 128 : 975-982 (2000). [PMID: 11098140]

[EC created 1972, modified 2011]