EC 1 - Oxidoreductases
EC 1.2 - Acting on the aldehyde or oxo group of donors
EC 1.2.1 - With NAD+ or NADP+ as acceptor
EC 1.2.1.3 - Aldehyde dehydrogenase (NAD+)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.2.1.3
Names
Accepted name:
aldehyde dehydrogenase (NAD+)
Other
names:
m-methylbenzaldehyde dehydrogenase
CoA-independent aldehyde dehydrogenase
NAD-aldehyde dehydrogenase
NAD-dependent 4-hydroxynonenal dehydrogenase
NAD-dependent aldehyde dehydrogenase
NAD-linked aldehyde dehydrogenase
propionaldehyde dehydrogenase
CoA-independent aldehyde dehydrogenase
NAD-aldehyde dehydrogenase
NAD-dependent 4-hydroxynonenal dehydrogenase
NAD-dependent aldehyde dehydrogenase
NAD-linked aldehyde dehydrogenase
propionaldehyde dehydrogenase
Systematic name:
aldehyde:NAD+ oxidoreductase
Reactions
-
16185 [IUBMB]+an aldehydeName origin: UniProt - CHECKED (C)Formula: CHOR
Charge: 0ChEBI compound status: CHECKED (C)+H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)NAD+Name origin: UniProt - CHECKED (C)Formula: C21H26N7O14P2
Charge: -1ChEBI compound status: CHECKED (C)=+a carboxylateName origin: UniProt - CHECKED (C)Formula: CO2R
Charge: -1ChEBI compound status: CHECKED (C)2+H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C) -
+acetaldehydeName origin: UniProt - CHECKED (C)Formula: C2H4O
Charge: 0ChEBI compound status: CHECKED (C)+H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)NAD+Name origin: UniProt - CHECKED (C)Formula: C21H26N7O14P2
Charge: -1ChEBI compound status: CHECKED (C)=+acetateName origin: UniProt - CHECKED (C)Formula: C2H3O2
Charge: -1ChEBI compound status: CHECKED (C)2+H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)
Comments:
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UM-BBD
,
UniPathway
Protein domains and families:
PROSITE:PDOC00068
Gene Ontology:
GO:0004029
,
GO:0043878
CAS Registry Number:
9028-86-8
References
-
Aldehyde dehydrogenases.In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 7, Academic Press, New York, 1963, 203-221
-
Aldehyde dehydrogenase, a diphosphopyridine nucleotide-linked enzyme.J. Biol. Chem. 177: 883-892 (1949).
[EC 1.2.1.3 created 1961 (EC 1.1.1.70 created 1965, incorporated 1978)]