EC 1 - Oxidoreductases
EC 1.2 - Acting on the aldehyde or oxo group of donors
EC 1.2.1 - With NAD+ or NADP+ as acceptor
EC 1.2.1.24 - Succinate-semialdehyde dehydrogenase (NAD+)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.2.1.24
Names
Accepted name:
succinate-semialdehyde dehydrogenase (NAD+)
Other
names:
succinate semialdehyde dehydrogenase (NAD+)
succinate semialdehyde:NAD+ oxidoreductase
succinic semialdehyde dehydrogenase (NAD+)
succinyl semialdehyde dehydrogenase (NAD+)
succinate semialdehyde:NAD+ oxidoreductase
succinic semialdehyde dehydrogenase (NAD+)
succinyl semialdehyde dehydrogenase (NAD+)
Systematic name:
succinate-semialdehyde:NAD+ oxidoreductase
Reaction
-
13217 [IUBMB]+H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)+NAD+Name origin: UniProt - CHECKED (C)Formula: C21H26N7O14P2
Charge: -1ChEBI compound status: CHECKED (C)succinate semialdehydeName origin: UniProt - CHECKED (C)Formula: C4H5O3
Charge: -1ChEBI compound status: CHECKED (C)=2+H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)+NADHName origin: UniProt - CHECKED (C)Formula: C21H27N7O14P2
Charge: -2ChEBI compound status: CHECKED (C)
Comments:
This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00068
Gene Ontology:
GO:0004777
CAS Registry Number:
9028-95-9
References
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Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain.Biochim. Biophys. Acta 52: 29-35 (1961). [PMID: 13860092]
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Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase.Arch. Biochem. Biophys. 266: 386-396 (1988). [PMID: 3190233]
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Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides.Plant Physiol. 121: 589-597 (1999). [PMID: 10517851]
[EC 1.2.1.24 created 1972, modified 2010]