EC - Succinate-semialdehyde dehydrogenase (NAD+)

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IntEnz Enzyme Nomenclature


Accepted name:
succinate-semialdehyde dehydrogenase (NAD+)
Other names:
succinate semialdehyde dehydrogenase (NAD+)
succinate semialdehyde:NAD+ oxidoreductase
succinic semialdehyde dehydrogenase (NAD+)
succinyl semialdehyde dehydrogenase (NAD+)
Systematic name:
succinate-semialdehyde:NAD+ oxidoreductase



This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC [succinate-semialdehyde dehydrogenase (NADP+)], and EC [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00068
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004777
CAS Registry Number: 9028-95-9
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Albers, R.W. and Koval, G.J.
    Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain.
    Biochim. Biophys. Acta 52 : 29-35 (1961). [PMID: 13860092]
  2. Ryzlak, M. T., Pietruszko, R.
    Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase.
    Arch. Biochem. Biophys. 266 : 386-396 (1988). [PMID: 3190233]
  3. Busch, K. B., Fromm, H.
    Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides.
    Plant Physiol. 121 : 589-597 (1999). [PMID: 10517851]

[EC created 1972, modified 2010]