EC - 2-oxoaldehyde dehydrogenase (NAD+)

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IntEnz Enzyme Nomenclature


Accepted name:
2-oxoaldehyde dehydrogenase (NAD+)
Other names:
2-ketoaldehyde dehydrogenase
α-ketoaldehyde dehydrogenase
NAD-dependent α-ketoaldehyde dehydrogenase
NAD-linked α-ketoaldehyde dehydrogenase
methylglyoxal dehydrogenase
Systematic name:
2-oxoaldehyde:NAD+ 2-oxidoreductase



Not identical with EC 2-oxoaldehyde dehydrogenase (NADP+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047551
CAS Registry Number: 37250-91-2


  1. Monder, C.
    α-Keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate.
    J. Biol. Chem. 242 : 4603-4609 (1967). [PMID: 4383524]
  2. Ray, M. and Ray, S.
    On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase.
    J. Biol. Chem. 257 : 10571-10574 (1982). [PMID: 7107626]
  3. Ray, S. and Ray, M.
    Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate.
    J. Biol. Chem. 257 : 10566-10570 (1982). [PMID: 7107625]

[EC created 1972, modified 1986]