EC 1 - Oxidoreductases
EC 1.2 - Acting on the aldehyde or oxo group of donors
EC 1.2.1 - With NAD+ or NADP+ as acceptor
EC 1.2.1.20 - Glutarate-semialdehyde dehydrogenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.2.1.20
Names
Accepted name:
glutarate-semialdehyde dehydrogenase
Other
name:
glutarate semialdehyde dehydrogenase
Systematic name:
glutarate-semialdehyde:NADP+ oxidoreductase
Reaction
- 5-oxopentanoate + NADP+ + H2O = glutarate + NADPH + H+
Comments:
The enzyme, characterized from multiple Pseudomonas strains, participates in L-lysine degradation. Unlike earlier claims, it prefers NADP+ to NAD+.
Links to other databases
Gene Ontology:
GO:0047949
CAS Registry Number:
9028-99-3
References
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Metabolism of L-lysine by bacterial enzymes. V. Glutaric semialdehyde dehydrogenase.J. Biochem. (Tokyo) 49 : 154-157 (1961).
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Glutaric semialdehyde dehydrogenase (Pseudomonas putida).Methods Enzymol 17B : 166-171 (1971).
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Catabolism of L-lysine by Pseudomonas aeruginosa.J Gen Microbiol 99 : 139-155 (1977). [PMID: 405455]
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Glutarate semialdehyde dehydrogenase of Pseudomonas. Purification, properties, and relation to L-lysine catabolism.J Biol Chem 252 : 7979-7986 (1977). [PMID: 914857]
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Prediction of missing enzyme genes in a bacterial metabolic network. Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa.FEBS J 274 : 2262-2273 (2007). [PMID: 17388807]
[EC 1.2.1.20 created 1965, modified 2021]