EC - Glutarate-semialdehyde dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
glutarate-semialdehyde dehydrogenase
Other name:
glutarate semialdehyde dehydrogenase
Systematic name:
glutarate-semialdehyde:NADP+ oxidoreductase



The enzyme, characterized from multiple Pseudomonas strains, participates in L-lysine degradation. Unlike earlier claims, it prefers NADP+ to NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047949
CAS Registry Number: 9028-99-3


  1. Ichihara, A. and Ichihara, E.A.
    Metabolism of L-lysine by bacterial enzymes. V. Glutaric semialdehyde dehydrogenase.
    J. Biochem. (Tokyo) 49 : 154-157 (1961).
  2. Chang, Y. F. and Adams, E.
    Glutaric semialdehyde dehydrogenase (Pseudomonas putida).
    Methods Enzymol 17B : 166-171 (1971).
  3. Fothergill, J. C., Guest, J. R.
    Catabolism of L-lysine by Pseudomonas aeruginosa.
    J Gen Microbiol 99 : 139-155 (1977). [PMID: 405455]
  4. Chang, Y. F., Adams, E.
    Glutarate semialdehyde dehydrogenase of Pseudomonas. Purification, properties, and relation to L-lysine catabolism.
    J Biol Chem 252 : 7979-7986 (1977). [PMID: 914857]
  5. Yamanishi, Y., Mihara, H., Osaki, M., Muramatsu, H., Esaki, N., Sato, T., Hizukuri, Y., Goto, S., Kanehisa, M.
    Prediction of missing enzyme genes in a bacterial metabolic network. Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa.
    FEBS J 274 : 2262-2273 (2007). [PMID: 17388807]

[EC created 1965, modified 2021]