EC - Pyruvate dehydrogenase system

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IntEnz Enzyme Nomenclature


Accepted name:
pyruvate dehydrogenase system
Other names:
pyruvate dehydrogenase complex
Systematic name:
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating)



The pyruvate dehydrogenase system (PDH) is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC, branched-chain α-keto acid dehydrogenase system, EC, 2-oxoglutarate dehydrogenase system, EC, glycine cleavage system, and EC, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3). The reaction catalysed by this system is the sum of three activities: EC, pyruvate dehydrogenase (acetyl-transferring) (E1), EC, dihydrolipoyllysine-residue acetyltransferase (E2), and EC, dihydrolipoyl dehydrogenase (E3). The mammalian system also includes E3 binding protein, which is involved in the interaction between the E2 and E3 subunits.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Reed, L. J., Pettit, F. H., Eley, M. H., Hamilton, L., Collins, J. H., Oliver, R. M.
    Reconstitution of the Escherichia coli pyruvate dehydrogenase complex.
    Proc Natl Acad Sci U S A 72 : 3068-3072 (1975). [PMID: 1103138]
  2. Bates, D. L., Danson, M. J., Hale, G., Hooper, E. A., Perham, R. N.
    Self-assembly and catalytic activity of the pyruvate dehydrogenase multienzyme complex of Escherichia coli.
    Nature 268 : 313-316 (1977). [PMID: 329143]
  3. Stanley, C. J., Packman, L. C., Danson, M. J., Henderson, C. E., Perham, R. N.
    Intramolecular coupling of active sites in the pyruvate dehydrogenase multienzyme complexes from bacterial and mammalian sources.
    Biochem. J. 195 : 715-721 (1981). [PMID: 7032507]
  4. Yang, H. C., Hainfeld, J. F., Wall, J. S., Frey, P. A.
    Quaternary structure of pyruvate dehydrogenase complex from Escherichia coli.
    J. Biol. Chem. 260 : 16049-16051 (1985). [PMID: 3905803]
  5. Patel, M. S., Roche, T. E.
    Molecular biology and biochemistry of pyruvate dehydrogenase complexes.
    FASEB J. 4 : 3224-3233 (1990). [PMID: 2227213]

[EC created 2020]