EC - Acetaldehyde dehydrogenase (acetylating)

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IntEnz Enzyme Nomenclature


Accepted name:
acetaldehyde dehydrogenase (acetylating)
Other names:
aldehyde dehydrogenase (acylating)
acylating acetaldehyde dehydrogenase
Systematic name:
acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)



Also acts, more slowly, on glycolaldehyde, propanal and butanal. In several bacterial species this enzyme forms a bifunctional complex with EC, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC, propanal dehydrogenase (propanoylating). Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. NADP+ can replace NAD+ but the rate of reaction is much slower [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00059
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008774
CAS Registry Number: 9028-91-5
UniProtKB/Swiss-Prot: (171) [show] [UniProt]


  1. Burton, R.M. and Stadtman, E.R.
    The oxidation of acetaldehyde to acetyl coenzyme A.
    J. Biol. Chem. 202 : 873-890 (1953). [PMID: 13061511]
  2. Smith, L.T. and Kaplan, N.O.
    Purification, properties, and kinetic mechanism of coenzyme A-linked aldehyde dehydrogenase from Clostridium kluyveri.
    Arch. Biochem. Biophys. 203 : 663-675 (1980). [PMID: 7458347]
  3. Powlowski, J., Sahlman, L. and Shingler, V.
    Purification and properties of the physically associated meta-cleavage pathway enzymes 4-hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600.
    J. Bacteriol. 175 : 377-385 (1993). [PMID: 8419288]
  4. Baker, P., Pan, D., Carere, J., Rossi, A., Wang, W., Seah, S. Y.
    Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.
    Biochemistry 48 : 6551-6558 (2009). [PMID: 19476337]
  5. Baker, P., Hillis, C., Carere, J., Seah, S. Y.
    Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
    Biochemistry 51 : 1942-1952 (2012). [PMID: 22316175]

[EC created 1961, modified 2006, modified 2011]