EC - Putidaredoxin—NAD+ reductase

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IntEnz Enzyme Nomenclature


Accepted name:
putidaredoxin—NAD+ reductase
Other names:
putidaredoxin reductase
camA (gene name)
Systematic name:
putidaredoxin:NAD+ oxidoreductase



Requires FAD. The enzyme from Pseudomonas putida reduces putidaredoxin. It contains a [2Fe-2S] cluster. Involved in the camphor monooxygenase system (see EC, camphor 5-monooxygenase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Roome, P. W., Philley, J. C., Peterson, J. A.
    Purification and properties of putidaredoxin reductase.
    J. Biol. Chem. 258 : 2593-2598 (1983). [PMID: 6401738]
  2. Koga, H., Yamaguchi, E., Matsunaga, K., Aramaki, H., Horiuchi, T.
    Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida.
    J. Biochem. 106 : 831-836 (1989). [PMID: 2613690]
  3. Peterson, J. A., Lorence, M. C., Amarneh, B.
    Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins.
    J. Biol. Chem. 265 : 6066-6073 (1990). [PMID: 2180940]
  4. Sevrioukova, I. F., Poulos, T. L.
    Putidaredoxin reductase, a new function for an old protein.
    J. Biol. Chem. 277 : 25831-25839 (2002). [PMID: 12011076]
  5. Sevrioukova, I. F., Garcia, C., Li, H., Bhaskar, B., Poulos, T. L.
    Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida.
    J. Mol. Biol. 333 : 377-392 (2003). [PMID: 14529624]
  6. Sevrioukova, I. F., Li, H., Poulos, T. L.
    Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase.
    J. Mol. Biol. 336 : 889-902 (2004). [PMID: 15095867]
  7. Smith, N., Mayhew, M., Holden, M. J., Kelly, H., Robinson, H., Heroux, A., Vilker, V. L., Gallagher, D. T.
    Structure of C73G putidaredoxin from Pseudomonas putida.
    Acta Crystallogr. D Biol. Crystallogr. 60 : 816-822 (2004). [PMID: 15103126]

[EC created 2012]