EC - Rubredoxin—NAD(P)+ reductase

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IntEnz Enzyme Nomenclature


Accepted name:
rubredoxin—NAD(P)+ reductase
Other names:
NAD(P)-rubredoxin oxidoreductase
NAD(P)H-rubredoxin oxidoreductase
dinucleotide phosphate reductase
rubredoxin-nicotinamide adenine
rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase
Systematic name:
rubredoxin:NAD(P)+ oxidoreductase




The enzyme from Pyrococcus furiosus requires FAD. It reduces a number of electron carriers, including benzyl viologen, menadione and 2,6-dichloroindophenol, but rubredoxin is the most efficient. Ferredoxin is not utilized.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015045 , GO:0015046


  1. Petitdemange, H., Blusson, H. and Gay, R.
    Detection of NAD(P)H-rubredoxin oxidoreductases in Clostridia.
    Anal. Biochem. 116 : 564-570 (1981). [PMID: 6274224]
  2. Ma, K. and Adams, M.W.W.
    A hyperactive NAD(P)H:rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus.
    J. Bacteriol. 181 : 5530-5533 (1999). [PMID: 10464233]

[EC created 1984, modified 2001]