EC - Ferredoxin—NAD+ reductase

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IntEnz Enzyme Nomenclature


Accepted name:
ferredoxin—NAD+ reductase
Other names:
NAD—ferredoxin reductase
NADH flavodoxin oxidoreductase
NADH—ferredoxin oxidoreductase
NADH—ferredoxin reductase
NADH—ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)
NADH—ferredoxinTOL reductase (component of toluene dioxygenase)
NADH2—ferredoxin oxidoreductase
ferredoxin reductase
ferredoxin-linked NAD reductase
ferredoxin—NAD reductase
ferredoxin—nicotinamide adenine dinucleotide reductase
reductase, reduced nicotinamide adenine dinucleotide—ferredoxin
Systematic name:
ferredoxin:NAD+ oxidoreductase




Contains FAD. Reaction (1) is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems. The alternative reaction (2) is written for a 2[4Fe-4S] ferredoxin, which transfers two electrons, and occurs in metabolism of anaerobic bacteria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008860
CAS Registry Number: 39369-37-4
UniProtKB/Swiss-Prot: (39) [show] [UniProt]


  1. Jungerman, K., Thauer, R.F., Leimenstoll, G. and Decker, K.
    Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia.
    Biochim. Biophys. Acta 305 : 268-280 (1973). [PMID: 4147457]
  2. Haigler, B. E., Gibson, D. T.
    Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816.
    J. Bacteriol. 172 : 457-464 (1990). [PMID: 2294092]
  3. Ramachandra, M., Seetharam, R., Emptage, M. H., Sariaslani, F. S.
    Purification and characterization of a soybean flour-inducible ferredoxin reductase of Streptomyces griseus.
    J. Bacteriol. 173 : 7106-7112 (1991). [PMID: 1938912]
  4. Shaw, J. P., Harayama, S.
    Purification and characterisation of the NADH:acceptor reductase component of xylene monooxygenase encoded by the TOL plasmid pWW0 of Pseudomonas putida mt-2.
    Eur. J. Biochem. 209 : 51-61 (1992). [PMID: 1327782]

[EC created 1976 as EC, transferred 1978 to EC, modified 2011]