EC - Ferredoxin—NADP+ reductase

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IntEnz Enzyme Nomenclature


Accepted name:
ferredoxin—NADP+ reductase
Other names:
NADP+:ferredoxin oxidoreductase
NADPH:ferredoxin oxidoreductase
TPNH-ferredoxin reductase
ferredoxin-NADP+ oxidoreductase
ferredoxin-NADP+ reductase
ferredoxin-TPN reductase
ferredoxin-nicotinamide adenine dinucleotide phosphate reductase
ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase
Systematic name:
ferredoxin:NADP+ oxidoreductase




A flavoprotein (FAD). In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe-2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004324
CAS Registry Number: 9029-33-8
UniProtKB/Swiss-Prot: (265) [show] [UniProt]


  1. Shin, M., Tagawa, K. and Arnon, D.I.
    Crystallization of ferredoxin-TPN reductase and its role in the photosynthetic apparatus of chloroplasts.
    Biochem. Z. 338: 84-96 (1963).
  2. Knaff, D. B., Hirasawa, M.
    Ferredoxin-dependent chloroplast enzymes.
    Biochim. Biophys. Acta 1056: 93-125 (1991). [PMID: 1671559]
  3. Karplus, P. A., Daniels, M. J., Herriott, J. R.
    Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family.
    Science 251: 60-66 (1991). [PMID: 1986412]

[EC created 1965 as EC, transferred 1972 as EC, transferred 1978 to EC, modified 2012]