EC 1.17.99.4 - Uracil/thymine dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.17.99.4

Names

Accepted name:
uracil/thymine dehydrogenase
Other names:
uracil oxidase
uracil-thymine oxidase
uracil dehydrogenase
Systematic name:
uracil:acceptor oxidoreductase

Reactions

Comments:

Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase (NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (β-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 [5]. Formerly EC 1.2.99.1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043835 , GO:0052620 , GO:0050383
CAS Registry Number: 9029-00-9

References

  1. Hayaishi, O. and Kornberg, A.
    Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes.
    J. Biol. Chem. 197: 717-723 (1952). [PMID: 12981104]
  2. Wang, T.P. and Lampen, J.O.
    Metabolism of pyrimidines by a soil bacterium.
    J. Biol. Chem. 194: 775-783 (1952). [PMID: 14927671]
  3. Wang, T.P. and Lampen, J.O.
    Uracil oxidase and the isolation of barbituric acid from uracil oxidation.
    J. Biol. Chem. 194: 785-791 (1952). [PMID: 14927672]
  4. Lara, F.J.S.
    On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations.
    J. Bacteriol. 64: 279-285 (1952). [PMID: 14955523]
  5. Soong, C.-L., Ogawa, J. and Shimizu, S.
    Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase.
    Biochem. Biophys. Res. Commun. 286: 222-226 (2001). [PMID: 11485332]

[EC 1.1.99.19 created 1961 as EC 1.2.99.1, transferred 1984 to EC 1.1.99.19, transferred 2006 to EC 1.17.99.4]