EC - Ethylbenzene hydroxylase

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IntEnz Enzyme Nomenclature


Accepted name:
ethylbenzene hydroxylase
Other name:
ethylbenzene dehydrogenase
Systematic name:
ethylbenzene:acceptor oxidoreductase




Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018693


  1. Kniemeyer, O. and Heider, J.
    Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidising molybdenum/iron-sulfur/heme enzyme.
    J. Biol. Chem. 276: 21381-21386 (2001). [PMID: 11294876]
  2. Johnson, H.A., Pelletier, D.A. and Spormann, A.M.
    Isolation and characterisation of anaerobic ethylbenzene dehydrogenase, a novel Mo-Fe-S enzyme.
    J. Bacteriol. 183: 4536-4542 (2001). [PMID: 11443088]

[EC created 2001]