EC 1.17.7.1 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)

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IntEnz Enzyme Nomenclature
EC 1.17.7.1

Names

Accepted name:
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
Other names:
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase [ambiguous]
(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) [incorrect]
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase [ambiguous]
gcpE (gene name)
ISPG (gene name)
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase
Systematic name:
(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase

Reaction

Cofactor

Comments:

An iron-sulfur protein found in plant chloroplasts and cyanobacteria that contains a [4Fe-4S] cluster [1]. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis [3]. Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3). The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046429
UniProtKB/Swiss-Prot: (27) [show] [UniProt]

References

  1. Okada, K. and Hase, T.
    Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1.
    J. Biol. Chem. 280: 20672-20679 (2005). [PMID: 15792953]
  2. Seemann, M., Wegner, P., Schünemann, V., Tse Sum Bui, B., Wolff, M., Marquet, A., Trautwein, A.X. and Rohmer, M.
    Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe-4S] protein.
    J. Biol. Inorg. Chem. 10: 131-137 (2005). [PMID: 15650872]
  3. Seemann, M., Tse Sum Bui, B., Wolff, M., Tritsch, D., Campos, N., Boronat, A., Marquet, A. and Rohmer, M.
    Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein.
    Angew. Chem. Int. Ed. Engl. 41: 4337-4339 (2002). [PMID: 12434382]
  4. Seemann, M., Tse Sum Bui, B., Wolff, M., Miginiac-Maslow, M., Rohmer, M.
    Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG.
    FEBS Lett. 580: 1547-1552 (2006). [PMID: 16480720]

[EC 1.17.7.1 created 2003 as EC 1.17.4.3, transferred 2009 to EC 1.17.7.1, modified 2014]