EC - Iron:rusticyanin reductase

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IntEnz Enzyme Nomenclature


Accepted name:
iron:rusticyanin reductase
Other name:
Systematic name:
Fe(II):rusticyanin oxidoreductase




Contains c-type heme. The enzyme in Acidithiobacillus ferrooxidans is a component of an electron transfer chain from Fe(II), comprising this enzyme, the copper protein rusticyanin, cytochrome c4, and cytochrome c oxidase (EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Blake, R. C., Shute, E. A.
    Respiratory enzymes of Thiobacillus ferrooxidans. Kinetic properties of an acid-stable iron:rusticyanin oxidoreductase.
    Biochemistry 33: 9220-9228 (1994). [PMID: 8049223]
  2. Appia-Ayme, C., Bengrine, A., Cavazza, C., Giudici-Orticoni, M. T., Bruschi, M., Chippaux, M., Bonnefoy, V.
    Characterization and expression of the co-transcribed cyc1 and cyc2 genes encoding the cytochrome c4 (c552) and a high-molecular-mass cytochrome c from Thiobacillus ferrooxidans ATCC 33020.
    FEMS Microbiol. Lett. 167: 171-177 (1998). [PMID: 9809418]
  3. Yarzabal, A., Brasseur, G., Ratouchniak, J., Lund, K., Lemesle-Meunier, D., DeMoss, J. A., Bonnefoy, V.
    The high-molecular-weight cytochrome c Cyc2 of Acidithiobacillus ferrooxidans is an outer membrane protein.
    J. Bacteriol. 184: 313-317 (2002). [PMID: 11741873]
  4. Yarzabal, A., Appia-Ayme, C., Ratouchniak, J., Bonnefoy, V.
    Regulation of the expression of the Acidithiobacillus ferrooxidans rus operon encoding two cytochromes c, a cytochrome oxidase and rusticyanin.
    Microbiology (Reading, Engl.) 150: 2113-2123 (2004). [PMID: 15256554]
  5. Taha, T. M., Kanao, T., Takeuchi, F., Sugio, T.
    Reconstitution of iron oxidase from sulfur-grown Acidithiobacillus ferrooxidans.
    Appl. Environ. Microbiol. 74: 6808-6810 (2008). [PMID: 18791023]
  6. Castelle, C., Guiral, M., Malarte, G., Ledgham, F., Leroy, G., Brugna, M., Giudici-Orticoni, M. T.
    A new iron-oxidizing/O2-reducing supercomplex spanning both inner and outer membranes, isolated from the extreme acidophile Acidithiobacillus ferrooxidans.
    J. Biol. Chem. 283: 25803-25811 (2008). [PMID: 18632666]
  7. Quatrini, R., Appia-Ayme, C., Denis, Y., Jedlicki, E., Holmes, D. S., Bonnefoy, V.
    Extending the models for iron and sulfur oxidation in the extreme acidophile Acidithiobacillus ferrooxidans.
    BMC Genomics 10: 394 (2009). [PMID: 19703284]

[EC created 2011 as EC, transferred 2011]