IntEnz

EC 1.16.8.1 - Cob(II)yrinic acid a,c-diamide reductase

IntEnz Enzyme Nomenclature
EC 1.16.8.1

Names

Reaction

• 24300 [IUBMB]
  2

  cob(I)yrinate a,c diamide

  cob(I)yrinate a,c diamide

  Name origin: UniProt - CHECKED (C)

  CHEBI:58575

  Formula: C45H56CoN6O12
  Charge: -5

  ChEBI compound status: CHECKED (C)

  

  +

  FMN

  FMN

  Name origin: UniProt - CHECKED (C)

  CHEBI:58210

  Formula: C17H18N4O9P
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  3

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  =

  2

  cob(II)yrinate a,c diamide

  cob(II)yrinate a,c diamide

  Name origin: UniProt - CHECKED (C)

  CHEBI:58537

  Formula: C45H56CoN6O12
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  FMNH₂

  FMNH2

  Name origin: UniProt - CHECKED (C)

  CHEBI:57618

  Formula: C17H21N4O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.

Links to other databases

References

1. Blanche F., Maton, L., Debussche, L. and Thibaut, D.
   Purification and characterization of cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans.
   J. Bacteriol. 174: 7452-7454 (1992). [PMID: 1429467]
2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C.
   The biosynthesis of adenosylcobalamin (vitamin B₁₂).
   Nat. Prod. Rep. 19: 390-412 (2002). [PMID: 12195810]

[EC 1.16.8.1 created 2004]