EC - Cob(II)yrinic acid a,c-diamide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
cob(II)yrinic acid a,c-diamide reductase
Other name:
cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase [incorrect]
Systematic name:
cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase



This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043784


  1. Blanche F., Maton, L., Debussche, L. and Thibaut, D.
    Purification and characterization of cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans.
    J. Bacteriol. 174 : 7452-7454 (1992). [PMID: 1429467]
  2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C.
    The biosynthesis of adenosylcobalamin (vitamin B12).
    Nat. Prod. Rep. 19 : 390-412 (2002). [PMID: 12195810]

[EC created 2004]