EC 1.16.8.1 - Cob(II)yrinic acid a,c-diamide reductase
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IntEnz Enzyme Nomenclature
EC 1.16.8.1
Names
Accepted name:
cob(II)yrinic acid a,c-diamide reductase
Other
name:
cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase
[incorrect]
Systematic name:
cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase
Reaction
- 2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid a,c-diamide + FMNH2
Comments:
This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.
Links to other databases
Gene Ontology:
GO:0043784
References
-
Purification and characterization of cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans.J. Bacteriol. 174 : 7452-7454 (1992). [PMID: 1429467]
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The biosynthesis of adenosylcobalamin (vitamin B12).Nat. Prod. Rep. 19 : 390-412 (2002). [PMID: 12195810]
[EC 1.16.8.1 created 2004]