EC 1.16.3.1 - Ferroxidase
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IntEnz Enzyme Nomenclature
EC 1.16.3.1
Names
Accepted name:
ferroxidase
Other
names:
caeruloplasmin
ceruloplasmin
ferro:O2 oxidoreductase
ferroxidase I
iron II:oxygen oxidoreductase
iron(II):oxygen oxidoreductase
iron oxidase
hephaestin
HEPH
ceruloplasmin
ferro:O2 oxidoreductase
ferroxidase I
iron II:oxygen oxidoreductase
iron(II):oxygen oxidoreductase
iron oxidase
hephaestin
HEPH
Systematic name:
Fe(II):oxygen oxidoreductase
Reaction
- 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O
Cofactor
Comments:
The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.
Links to other databases
Protein domains and families:
PROSITE:PDOC00076
Gene Ontology:
GO:0004322
CAS Registry Numbers:
104404-69-5
9031-37-2
References
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Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin).J. Biol. Chem. 241 : 5053-5059 (1966). [PMID: 5925868]
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Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex.J. Biol. Chem. 242 : 2653-2657 (1967). [PMID: 6027241]
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An X-ray structural study of human ceruloplasmin in relation to ferroxidase activity.J. Biol. Inorg. Chem. 2 : 454-463 (1997).
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A new iron oxidase from a moderately thermophilic iron oxidizing bacterium strain TI-1.Eur. J. Biochem. 268 : 1653-1658 (2001). [PMID: 11248684]
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Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice.Blood 103 : 3933-3939 (2004). [PMID: 14751926]
[EC 1.16.3.1 created 1972, modified 2011]