IntEnz

EC 1.16.1.5 - Aquacobalamin reductase (NADPH)

IntEnz Enzyme Nomenclature
EC 1.16.1.5

Names

Reaction

• 20752 [IUBMB]
  2

  cob(II)alamin

  cob(II)alamin

  Name origin: UniProt - CHECKED (C)

  CHEBI:16304

  Formula: C62H88CoN13O14P
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NADP⁺

  NADP(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:58349

  Formula: C21H25N7O17P3
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  =

  2

  aquacob(III)alamin

  aquacob(III)alamin

  Name origin: UniProt - CHECKED (C)

  CHEBI:15852

  Formula: C62H90CoN13O15P
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADPH

  NADPH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57783

  Formula: C21H26N7O17P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

Cofactor

• flavoprotein

Comments:

A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.

Links to other databases

References

1. Watanabe, F., Oki, Y., Nakano, Y. and Kitaoka, S.
   Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
   J. Biol. Chem. 262: 11514-11518 (1987). [PMID: 3114247]
2. Watanabe, F., Yamaji, R., Isegawa, Y., Yamamoto, T., Tamura, Y. and Nakano, Y.
   Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
   Arch. Biochem. Biophys. 305: 421-427 (1993). [PMID: 8373179]

[EC 1.16.1.5 created 1989 as EC 1.6.99.11, transferred 2002 to EC 1.16.1.5]