EC - Aquacobalamin reductase (NADPH)

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IntEnz Enzyme Nomenclature


Accepted name:
aquacobalamin reductase (NADPH)
Other names:
NADPH-linked aquacobalamin reductase
NADPH2:aquacob(III)alamin oxidoreductase
aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase
NADPH:aquacob(III)alamin oxidoreductase
Systematic name:
cob(II)alamin:NADP+ oxidoreductase




A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050444
CAS Registry Number: 110777-32-7


  1. Watanabe, F., Oki, Y., Nakano, Y. and Kitaoka, S.
    Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
    J. Biol. Chem. 262: 11514-11518 (1987). [PMID: 3114247]
  2. Watanabe, F., Yamaji, R., Isegawa, Y., Yamamoto, T., Tamura, Y. and Nakano, Y.
    Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
    Arch. Biochem. Biophys. 305: 421-427 (1993). [PMID: 8373179]

[EC created 1989 as EC, transferred 2002 to EC]