EC 1.16.1.10 - Ferric-chelate reductase [NAD(P)H]

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IntEnz Enzyme Nomenclature
EC 1.16.1.10

Names

Accepted name:
ferric-chelate reductase [NAD(P)H]
Other name:
ferric reductase [ambiguous]
Systematic name:
Fe(II)-siderophore:NAD(P)+ oxidoreductase

Reactions

Cofactor

Comments:

A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Vadas, A., Monbouquette, H. G., Johnson, E., Schroder, I.
    Identification and characterization of a novel ferric reductase from the hyperthermophilic Archaeon Archaeoglobus fulgidus.
    J. Biol. Chem. 274 : 36715-36721 (1999). [PMID: 10593977]
  2. Chiu, H. J., Johnson, E., Schroder, I., Rees, D. C.
    Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+.
    Structure 9 : 311-319 (2001). [PMID: 11525168]

[EC 1.16.1.10 created 2014]