EC - Cyclooctatin synthase

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IntEnz Enzyme Nomenclature


Accepted name:
cyclooctatin synthase
Other name:
Systematic name:
cyclooctat-9-ene-5,7-diol,hydrogen-donor:oxygen oxidoreductase (18-hydroxylating)



Isolated from the bacterium Streptomyces melanosporofaciens M1614-43f2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kim, S. Y., Zhao, P., Igarashi, M., Sawa, R., Tomita, T., Nishiyama, M., Kuzuyama, T.
    Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
    Chem. Biol. 16 : 736-743 (2009). [PMID: 19635410]
  2. Gorner, C., Schrepfer, P., Redai, V., Wallrapp, F., Loll, B., Eisenreich, W., Haslbeck, M., Bruck, T.
    Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids.
    Microb. Cell Fact. 15 : 86 (2016). [PMID: 27216162]

[EC created 2018]