EC - Lytic cellulose monooxygenase (C4-dehydrogenating)

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IntEnz Enzyme Nomenclature


Accepted name:
lytic cellulose monooxygenase (C4-dehydrogenating)
Systematic name:
cellulose, hydrogen-donor:oxygen oxidoreductase (D-glucosyl 4-dehydrogenating)




This copper-containing enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner. The cellulose fragments that are formed contain a 4-dehydro-D-glucose residue at the non-reducing end. Some enzymes also oxidize cellulose at the C-1 position of the reducing end forming a D-glucono-1,5-lactone residue [cf. EC, lytic cellulose monooxygenase (C1-hydroxylating)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Beeson, W. T., Phillips, C. M., Cate, J. H., Marletta, M. A.
    Oxidative cleavage of cellulose by fungal copper-dependent polysaccharide monooxygenases.
    J. Am. Chem. Soc. 134 : 890-892 (2012). [PMID: 22188218]
  2. Li, X., Beeson, W. T., Phillips, C. M., Marletta, M. A., Cate, J. H.
    Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases.
    Structure 20 : 1051-1061 (2012). [PMID: 22578542]
  3. Forsberg, Z., Mackenzie, A. K., Sørlie, M., Røhr, Å. K., Helland, R., Arvai, A. S., Vaaje-Kolstad, G., Eijsink, V. G.
    Structural and functional characterization of a conserved pair of bacterial cellulose-oxidizing lytic polysaccharide monooxygenases.
    Proc. Natl. Acad. Sci. U.S.A. 111 : 8446-8451 (2014). [PMID: 24912171]
  4. Borisova, A. S., Isaksen, T., Dimarogona, M., Kognole, A. A., Mathiesen, G., Varnai, A., Røhr, Å. K., Payne, C. M., Sørlie, M., Sandgren, M., Eijsink, V. G.
    Structural and Functional Characterization of a Lytic Polysaccharide Monooxygenase with Broad Substrate Specificity.
    J. Biol. Chem. 290 : 22955-22969 (2015). [PMID: 26178376]
  5. Patel, I., Kracher, D., Ma, S., Garajova, S., Haon, M., Faulds, C. B., Berrin, J. G., Ludwig, R., Record, E.
    Salt-responsive lytic polysaccharide monooxygenases from the mangrove fungus Pestalotiopsis sp. NCi6.
    Biotechnol Biofuels 9 : 108 (2016). [PMID: 27213015]

[EC created 2017]