EC - L-cysteinyl-L-histidinylsulfoxide synthase

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IntEnz Enzyme Nomenclature


Accepted name:
L-cysteinyl-L-histidinylsulfoxide synthase
Other name:
Systematic name:
L-histidine,L-cysteine:oxygen [S-(L-histidin-5-yl)-L-cysteine S-oxide-forming]




Requires Fe2+ for activity. The enzyme participates in ovothiol biosynthesis. It also has some activity as EC, cysteine dioxygenase, and can perform the reaction of EC, γ-glutamyl hercynylcysteine sulfoxide synthase, albeit with low activity [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Braunshausen, A., Seebeck, F. P.
    Identification and characterization of the first ovothiol biosynthetic enzyme.
    J. Am. Chem. Soc. 133 : 1757-1759 (2011). [PMID: 21247153]
  2. Song, H., Leninger, M., Lee, N., Liu, P.
    Regioselectivity of the oxidative C-S bond formation in ergothioneine and ovothiol biosyntheses.
    Org. Lett. 15 : 4854-4857 (2013). [PMID: 24016264]
  3. Mashabela, G. T., Seebeck, F. P.
    Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis.
    Chem. Commun. (Camb.) 49 : 7714-7716 (2013). [PMID: 23877651]
  4. Song, H., Her, A. S., Raso, F., Zhen, Z., Huo, Y., Liu, P.
    Cysteine oxidation reactions catalyzed by a mononuclear non-heme iron enzyme (OvoA) in ovothiol biosynthesis.
    Org. Lett. 16 : 2122-2125 (2014). [PMID: 24684381]

[EC created 2015]