EC - Diapolycopene oxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
diapolycopene oxygenase
Other name:
crtP [ambiguous]
Systematic name:
4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating)



Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Mijts, B. N., Lee, P. C., Schmidt-Dannert, C.
    Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution.
    Chem. Biol. 12 : 453-460 (2005). [PMID: 15850982]
  2. Tao, L., Schenzle, A., Odom, J. M., Cheng, Q.
    Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.
    Appl. Environ. Microbiol. 71 : 3294-3301 (2005). [PMID: 15933032]

[EC created 2011]