EC 1.14.99.44 - Diapolycopene oxygenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.14.99.44

Names

Accepted name:
diapolycopene oxygenase
Other name:
crtP [ambiguous]
Systematic name:
4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating)

Reaction

Comments:

Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Mijts, B. N., Lee, P. C., Schmidt-Dannert, C.
    Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution.
    Chem. Biol. 12 : 453-460 (2005). [PMID: 15850982]
  2. Tao, L., Schenzle, A., Odom, J. M., Cheng, Q.
    Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.
    Appl. Environ. Microbiol. 71 : 3294-3301 (2005). [PMID: 15933032]

[EC 1.14.99.44 created 2011]