EC 1.14.99.4 - Progesterone monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.99.4

Names

Accepted name:
progesterone monooxygenase
Other name:
progesterone hydroxylase
Systematic name:
progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)

Reaction

Comments:

Has a wide specificity. A single enzyme from Cylindrocarpon radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 4-androstene-3,17-dione monooxygenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050214
CAS Registry Number: 37256-85-2

References

  1. Rahim, M.A. and Sih, C.J.
    Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain.
    J. Biol. Chem. 241: 3615-3623 (1966).

[EC 1.14.99.4 created 1972, modified 1999]