EC - Ammonia monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
ammonia monooxygenase
Other name:
Systematic name:
ammonia,donor:oxygen oxidoreductase (hydroxylamine-producing)




Contains copper and possibly nonheme iron. The donor is membrane-bound. Electrons are derived indirectly from ubiquinol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018597


  1. Hyman, M. R., Page, C. L., Arp, D. J.
    Oxidation of methyl fluoride and dimethyl ether by ammonia monooxygenase in Nitrosomonas europaea.
    Appl. Environ. Microbiol. 60 : 3033-3035 (1994). [PMID: 8085841]
  2. Bergmann, D. J., Hooper, A. B.
    Sequence of the gene, amoB, for the 43-kDa polypeptide of ammonia monoxygenase of Nitrosomonas europaea.
    Biochem. Biophys. Res. Commun. 204 : 759-762 (1994). [PMID: 7980540]
  3. Holmes, A. J., Costello, A., Lidstrom, M. E., Murrell, J. C.
    Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related.
    FEMS Microbiol. Lett. 132 : 203-208 (1995). [PMID: 7590173]
  4. Zahn, J. A., Arciero, D. M., Hooper, A. B., DiSpirito, A. A.
    Evidence for an iron center in the ammonia monooxygenase from Nitrosomonas europaea.
    FEBS Lett. 397 : 35-38 (1996). [PMID: 8941709]
  5. Moir, J. W., Crossman, L. C., Spiro, S., Richardson, D. J.
    The purification of ammonia monooxygenase from Paracoccus denitrificans.
    FEBS Lett. 387 : 71-74 (1996). [PMID: 8654570]
  6. Whittaker, M., Bergmann, D., Arciero, D., Hooper, A. B.
    Electron transfer during the oxidation of ammonia by the chemolithotrophic bacterium Nitrosomonas europaea.
    Biochim. Biophys. Acta 1459 : 346-355 (2000). [PMID: 11004450]
  7. Arp, D. J., Sayavedra-Soto, L. A., Hommes, N. G.
    Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea.
    Arch. Microbiol. 178 : 250-255 (2002). [PMID: 12209257]
  8. Gilch, S., Meyer, O., Schmidt, I.
    A soluble form of ammonia monooxygenase in Nitrosomonas europaea.
    Biol. Chem. 390 : 863-873 (2009). [PMID: 19453274]
  9. Rasche, M. E., Hicks, R. E., Hyman, M. R., Arp, D. J.
    Oxidation of monohalogenated ethanes and n-chlorinated alkanes by whole cells of Nitrosomonas europaea.
    J. Bacteriol. 172 : 5368-5373 (1990). [PMID: 2394686]

[EC created 2010]