EC 1.14.99.12 - Androst-4-ene-3,17-dione monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.99.12

Names

Accepted name:
androst-4-ene-3,17-dione monooxygenase
Other names:
4-androstene-3,17-dione monooxygenase
androst-4-ene-3,17-dione 17-oxidoreductase
androst-4-ene-3,17-dione hydroxylase
androstene-3,17-dione hydroxylase
androstenedione monooxygenase
Systematic name:
androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)

Reaction

Comments:

Has a wide specificity. A single enzyme from Cylindrocarpon radicicola(EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.4.99.4 aralkylamine dehydrogenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047096
CAS Registry Number: 37256-74-9

References

  1. Prairie, R.L. and Talalay, P.
    Enzymatic formation of testololactone.
    Biochemistry 2: 203-208 (1963).

[EC 1.14.99.12 created 1972, modified 1999]