EC - Prostaglandin-endoperoxide synthase

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IntEnz Enzyme Nomenclature


Accepted name:
prostaglandin-endoperoxide synthase
Other names:
(PG)H synthase
PG synthetase
fatty acid cyclooxygenase
prostaglandin G/H synthase
prostaglandin endoperoxide synthetase
prostaglandin synthase
prostaglandin synthetase
Systematic name:
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase



This enzyme acts both as a dioxygenase and as a peroxidase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004666
CAS Registry Number: 9055-65-6
UniProtKB/Swiss-Prot: (25) [show] [UniProt]


  1. DeWitt, D.L. and Smith, W.L.
    Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
    Proc. Natl. Acad. Sci. USA 85 : 1412-1416 (1988). [PMID: 3125548]
  2. Ohki, S., Ogino, N., Yamamoto, S. and Hayaishi, O.
    Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
    J. Biol. Chem. 254 : 829-836 (1979). [PMID: 104998]

[EC created 1972, modified 1990]