EC - Tyrosine isonitrile desaturase

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IntEnz Enzyme Nomenclature


Accepted name:
tyrosine isonitrile desaturase
Other name:
pvcB (gene name)
Systematic name:
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase



The enzyme is a member of the Fe2+, 2-oxoglutarate-dependent oxygenases and requires Fe2+. It has been characterized from bacteria that form the isonitrile-functionalized compound paerucumarin. cf. EC, L-tyrosine isonitrile desaturase/decarboxylase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Clarke-Pearson, M. F., Brady, S. F.
    Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa.
    J. Bacteriol. 190 : 6927-6930 (2008). [PMID: 18689486]
  2. Drake, E. J., Gulick, A. M.
    Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.
    J. Mol. Biol. 384 : 193-205 (2008). [PMID: 18824174]
  3. Zhu, J., Lippa, G. M., Gulick, A. M., Tipton, P. A.
    Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products.
    Biochemistry 54 : 2659-2669 (2015). [PMID: 25866990]

[EC created 2018]