EC - (5R)-carbapenem-3-carboxylate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
(5R)-carbapenem-3-carboxylate synthase
Other name:
carC (gene name)
Systematic name:
(3S,5S)-carbapenam-3-carboxylate,2-oxoglutarate:oxygen oxidoreductase (dehydrating)




Requires Fe2+. The enzyme is involved in the biosynthesis of the carbapenem β-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. It catalyses a stereoinversion at C5 and introduces a double bond between C-2 and C-3.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Clifton, I. J., Doan, L. X., Sleeman, M. C., Topf, M., Suzuki, H., Wilmouth, R. C., Schofield, C. J.
    Crystal structure of carbapenem synthase (CarC).
    J. Biol. Chem. 278 : 20843-20850 (2003). [PMID: 12611886]
  2. Stapon, A., Li, R., Townsend, C. A.
    Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline.
    J. Am. Chem. Soc. 125 : 8486-8493 (2003). [PMID: 12848554]
  3. Sleeman, M. C., Smith, P., Kellam, B., Chhabra, S. R., Bycroft, B. W., Schofield, C. J.
    Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).
    Chembiochem 5 : 879-882 (2004). [PMID: 15174175]

[EC created 2013]