EC - Tyrosine isonitrile desaturase/decarboxylase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
tyrosine isonitrile desaturase/decarboxylase
Other name:
pvcB (gene name)
Systematic name:
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase (decarboxylating)



The enzyme, characterized from the bacterium Xenorhabdus nematophila, is involved in rhabduscin biosynthesis. The enzyme is a member of the Fe2+, 2-oxoglutarate-dependent oxygenases. It is similar to EC, L-tyrosine isonitrile desaturase; however, the latter does not catalyse a decarboxylation of the substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Crawford, J. M., Portmann, C., Zhang, X., Roeffaers, M. B., Clardy, J.
    Small molecule perimeter defense in entomopathogenic bacteria.
    Proc. Natl. Acad. Sci. U.S.A. 109 : 10821-10826 (2012). [PMID: 22711807]
  2. Zhu, J., Lippa, G. M., Gulick, A. M., Tipton, P. A.
    Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products.
    Biochemistry 54 : 2659-2669 (2015). [PMID: 25866990]

[EC created 2018]