EC - Berbamunine synthase

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IntEnz Enzyme Nomenclature


Accepted name:
berbamunine synthase
Other name:
(S)-N-methylcoclaurine oxidase (C-O phenol-coupling)
Systematic name:
(S)-N-methylcoclaurine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (C-O phenol-coupling)




A cytochrome P450 (heme-thiolate) protein found in plants. Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine. Formerly EC and EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047054
CAS Registry Number: 144941-42-4


  1. Stadler, R. and Zenk, M.H.
    The purification and characterization of a unique cytochrome P-450 enzyme from Berberis stolifera plant cell cultures.
    J. Biol. Chem. 268: 823-831 (1993). [PMID: 8380416]

[EC created 1999 as EC, transferred 2002 to EC, transferred 2018 to EC]