EC - Secologanin synthase

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IntEnz Enzyme Nomenclature


Accepted name:
secologanin synthase
Systematic name:
loganin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (ring-cleaving)




A cytochrome P450 (heme-thiolate) protein. Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050616
CAS Registry Number: 258339-71-8


  1. Yamamoto, H., Katano, N., Ooi, A. and Inoue, K.
    Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P-450.
    Phytochemistry 53 : 7-12 (2000). [PMID: 10656401]
  2. Irmler, S., Schröder, G., St-Pierre, B., Crouch, N.P., Hotze, M., Schmidt, J., Strack, D., Matern, U. and Schröder, J.
    Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P-450 CYP72A1 as secologanin synthase.
    Plant J. 24 : 797-804 (2000). [PMID: 11135113]
  3. Yamamoto, H., Katano, N., Ooi, Y. and Inoue, K.
    Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures.
    Phytochemistry 50 : 417-422 (1999).

[EC created 2002, deleted 2018]