EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 22.214.171.124 - Secologanin synthase
IntEnz view ENZYME view
IntEnz Enzyme Nomenclature
loganin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (ring-cleaving)
- loganin + reduced NADPHhemoprotein reductase + O2 = secologanin + oxidized NADPHhemoprotein reductase + 2 H2O
A cytochrome P450 (heme-thiolate) protein. Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids. Formerly EC 126.96.36.199.
Links to other databases
Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Gene Ontology: GO:0050616
CAS Registry Number: 258339-71-8
Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P-450.Phytochemistry 53 : 7-12 (2000). [PMID: 10656401]
Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P-450 CYP72A1 as secologanin synthase.Plant J. 24 : 797-804 (2000). [PMID: 11135113]
Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures.Phytochemistry 50 : 417-422 (1999).
[EC 188.8.131.52 created 2002, deleted 2018]