EC 1.14.19.55 - 4-hydroxybenzoate brominase (decarboxylating)

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IntEnz Enzyme Nomenclature
EC 1.14.19.55

Names

Accepted name:
4-hydroxybenzoate brominase (decarboxylating)
Other name:
bmp5 (gene name)
Systematic name:
4-hydroxybenzoate:NADPH oxidoreductase (brominating, decarboxylating)

Reactions

Cofactor

Comments:

Contains FAD. The enzyme, described from epiphytic marine bacteria of the genera Pseudoalteromonas and Marinomonas, is an unusual single-component FAD-dependent halogenase that contains a distinct NAD(P)H binding domain and does not require an additional flavin reductase for activity. The enzyme catalyses a bromination of its substrate, followed by a second bromination concurrent with decarboxylation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Agarwal, V., El Gamal, A. A., Yamanaka, K., Poth, D., Kersten, R. D., Schorn, M., Allen, E. E., Moore, B. S.
    Biosynthesis of polybrominated aromatic organic compounds by marine bacteria.
    Nat. Chem. Biol. 10 : 640-647 (2014). [PMID: 24974229]
  2. Agarwal, V., Moore, B. S.
    Enzymatic synthesis of polybrominated dioxins from the marine environment.
    ACS Chem. Biol. 9 : 1980-1984 (2014). [PMID: 25061970]

[EC 1.14.19.55 created 2018]