EC 1 - Oxidoreductases
EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 1.14.19 - With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
EC 1.14.19.37 - Acyl-CoA 5-desaturase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.14.19.37
Names
Accepted name:
acyl-CoA 5-desaturase
Other
name:
acyl-CoA 5-desaturase (non-methylene-interrupted)
Systematic name:
acyl-CoA,acceptor:oxygen oxidoreductase (5,6 cis-dehydrogenating)
Reactions
- (1) (11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + 2 H2O
- (2) (11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + 2 H2O
Comments:
The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44 acyl-CoA (8-3)-desaturase.
Links to other databases
UniProtKB/Swiss-Prot:
References
-
Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 Delta5-desaturase responsible for the synthesis of sciadonic acid.Plant Physiol. 144 : 455-467 (2007). [PMID: 17384161]
[EC 1.14.19.37 created 2015]