EC - Acyl-CoA 5-desaturase

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IntEnz Enzyme Nomenclature


Accepted name:
acyl-CoA 5-desaturase
Other name:
acyl-CoA 5-desaturase (non-methylene-interrupted)
Systematic name:
acyl-CoA,acceptor:oxygen oxidoreductase (5,6 cis-dehydrogenating)



The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC acyl-CoA (8-3)-desaturase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Sayanova, O., Haslam, R., Venegas Caleron, M., Napier, J. A.
    Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 Delta5-desaturase responsible for the synthesis of sciadonic acid.
    Plant Physiol. 144 : 455-467 (2007). [PMID: 17384161]

[EC created 2015]