EC 1.14.19.2 - Stearoyl-[acyl-carrier-protein] 9-desaturase

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IntEnz Enzyme Nomenclature
EC 1.14.19.2

Names

Accepted name:
stearoyl-[acyl-carrier-protein] 9-desaturase
Other names:
stearyl acyl carrier protein desaturase
stearyl-ACP desaturase
acyl-[acyl-carrier-protein] desaturase
acyl-[acyl-carrier protein],hydrogen-donor:oxygen oxidoreductase
Systematic name:
stearoyl-[acyl-carrier protein],reduced ferredoxin:oxygen oxidoreductase (9,10 cis-dehydrogenating)

Reaction

Comments:

The enzyme is found in the lumen of plastids, where de novo biosynthesis of fatty acids occurs, and acts on freshly synthesized saturated fatty acids that are still linked to acyl-carrier protein. The enzyme determines the position of the double bond by its distance from the carboxylic acid end of the fatty acid. It also acts on palmitoyl-[acyl-carrier-protein].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00399
Structural data: CSA , EC2PDB
Gene Ontology: GO:0045300 , GO:0102786
CAS Registry Number: 37256-86-3
UniProtKB/Swiss-Prot: (30) [show] [UniProt]

References

  1. Jaworski, J.G. and Stumpf, P.K.
    Fat metabolism in higher plants. Properties of a soluble stearyl-acyl carrier protein desaturase from maturing Carthamus tinctorius.
    Arch. Biochem. Biophys. 162: 158-165 (1974). [PMID: 4831331]
  2. Nagai, J. and Bloch, K.
    Enzymatic desaturation of stearyl acyl carrier protein.
    J. Biol. Chem. 243: 4626-4633 (1968). [PMID: 4300868]
  3. Shanklin, J., Somerville, C.
    Stearoyl-acyl-carrier-protein desaturase from higher plants is structurally unrelated to the animal and fungal homologs.
    Proc. Natl. Acad. Sci. U.S.A. 88: 2510-2514 (1991). [PMID: 2006187]
  4. Cahoon, E. B., Lindqvist, Y., Schneider, G., Shanklin, J.
    Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position.
    Proc. Natl. Acad. Sci. U.S.A. 94: 4872-4877 (1997). [PMID: 9144157]
  5. Cao, Y., Xian, M., Yang, J., Xu, X., Liu, W., Li, L.
    Heterologous expression of stearoyl-acyl carrier protein desaturase (S-ACP-DES) from Arabidopsis thaliana in Escherichia coli.
    Protein Expr. Purif. 69: 209-214 (2010). [PMID: 19716420]

[EC 1.14.19.2 created 1972 as EC 1.14.99.6, modified 2000, transferred 2000 to EC 1.14.19.2, modified 2015]