IntEnz - EC 1.14.19.1

EC 1 - Oxidoreductases

EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O₂

EC 1.14.19 - With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

EC 1.14.19.1 - Stearoyl-CoA 9-desaturase

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IntEnz Enzyme Nomenclature
EC 1.14.19.1

Names

Accepted name:

stearoyl-CoA 9-desaturase

Other names:

Δ⁹-desaturase
acyl-CoA desaturase
fatty acid desaturase
stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase
stearoyl-CoA desaturase

Systematic name:

stearoyl-CoA,ferrocytochrome-b₅:oxygen oxidoreductase (9,10-dehydrogenating)

Reaction

19721 [IUBMB]

[Fe(II)-cytochrome b₅]

GENERIC:10438

Is ROOT: no
ROOT compound: GENERIC:9753

Number of residues: 1

Fe²⁺

Name origin: UniProt - CHECKED (C)

CHEBI:29033

Formula: Fe
Charge: 2

Position: undefined

ChEBI compound status: CHECKED (C)

H⁺

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

O₂

Name origin: UniProt - CHECKED (C)

CHEBI:15379

Formula: O2
Charge: 0

ChEBI compound status: CHECKED (C)

octadecanoyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57394

Formula: C39H66N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

(9Z)-octadecenoyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57387

Formula: C39H64N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

[Fe(III)-cytochrome b₅]

GENERIC:10439

Is ROOT: no
ROOT compound: GENERIC:9753

Number of residues: 1

Fe³⁺

Name origin: UniProt - CHECKED (C)

CHEBI:29034

Formula: Fe
Charge: 3

Position: undefined

ChEBI compound status: CHECKED (C)

H₂O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

Cofactor

Fe cation

Comments:

An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b₅ and EC 1.6.2.2, cytochrome-b₅ reductase. The ferricytochrome b₅ produced is reduced by NADH and cytochrome-b₅ reductase (EC 1.6.2.2).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Protein domains and families: PROSITE:PDOC00399

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004768

CAS Registry Number: 9014-34-0

UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

Fulco, A.J. and Bloch, K.

Cofactor requirements for the formation of Δ⁹-unsaturated fatty acids in Mycobacterium phlei.

J. Biol. Chem. 239: 993-997 (1964). [PMID: 14167617]
Oshino, N., Imai, Y. and Sato, R.

Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes.

Biochim. Biophys. Acta 128: 13-27 (1966). [PMID: 4382040]
Oshino, N., Imai, Y. and Sato, R.

A function of cytochrome b₅ in fatty acid desaturation by rat liver microsomes.

J. Biochem. (Tokyo) 69: 155-167 (1971). [PMID: 5543646]
Strittmatter, P., Sputz, L., Corcoran, D., Rogers, M.J., Setlow, B. and Redline, R.

Purification and properties of rat liver microsomal stearyl coenzyme A desaturase.

Proc. Natl. Acad. Sci. USA 71: 4565-4569 (1974). [PMID: 4373719]

[EC 1.14.19.1 created 1972 as EC 1.14.99.5, modified 1986, modified 2000, transferred 2000 to EC 1.14.19.1, modified 2003]