EC 1.14.15.22 - Vitamin D 1,25-hydroxylase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.14.15.22

Names

Accepted name:
vitamin D 1,25-hydroxylase
Other names:
CYP105A1
Streptomyces griseolus cytochrome P450SU-1
Systematic name:
calciol,ferredoxin:oxygen oxidoreductase (1,25-hydroxylating)

Reactions

Comments:

A P-450 (heme-thiolate) enzyme found in the bacterium Streptomyces griseolus. cf. EC 1.14.14.24, vitamin D 25-hydroxylase and EC 1.14.15.18, calcidiol 1-monooxygenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Sawada, N., Sakaki, T., Yoneda, S., Kusudo, T., Shinkyo, R., Ohta, M., Inouye, K.
    Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1.
    Biochem. Biophys. Res. Commun. 320: 156-164 (2004). [PMID: 15207715]
  2. Sugimoto, H., Shinkyo, R., Hayashi, K., Yoneda, S., Yamada, M., Kamakura, M., Ikushiro, S., Shiro, Y., Sakaki, T.
    Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3.
    Biochemistry 47: 4017-4027 (2008). [PMID: 18314962]

[EC 1.14.15.22 created 2016]