EC - trans-cinnamate 4-monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
trans-cinnamate 4-monooxygenase
Other names:
t-cinnamic acid hydroxylase
trans-cinnamate 4-hydroxylase
trans-cinnamic acid 4-hydroxylase
cinnamate 4-hydroxylase
cinnamate 4-monooxygenase
cinnamate hydroxylase
cinnamic 4-hydroxylase
cinnamic acid 4-hydroxylase
cinnamic acid 4-monooxygenase
cinnamic acid p-hydroxylase
cytochrome P450 cinnamate 4-hydroxylase
Systematic name:
trans-cinnamate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)




A cytochrome P450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016710
CAS Registry Number: 9077-75-2
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. Potts, J.R.M., Weklych, R. and Conn, E.E.
    The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450.
    J. Biol. Chem. 249 : 5019-5026 (1974). [PMID: 4153152]
  2. Russell, D.W. and Conn, E.E.
    The cinnamic acid 4-hydroxylase of pea seedlings.
    Arch. Biochem. Biophys. 122 : 256-268 (1967). [PMID: 4383827]
  3. Pierrel, M. A., Batard, Y., Kazmaier, M., Mignotte-Vieux, C., Durst, F., Werck-Reichhart, D.
    Catalytic properties of the plant cytochrome P450 CYP73 expressed in yeast. Substrate specificity of a cinnamate hydroxylase.
    Eur. J. Biochem. 224 : 835-844 (1994). [PMID: 7925408]

[EC created 1976 as EC, transferred 2018 to EC]