EC 1.14.14.90 - Isoflavone 2'-hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.14.90

Names

Accepted name:
isoflavone 2'-hydroxylase
Other names:
isoflavone 2'-monooxygenase
CYP81E1
CYP Ge-3
Systematic name:
isoflavone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating)

Reactions

Cofactor

Comments:

A cytochrome P450 (heme-thiolate) protein. Acts on daidzein, formononetin and genistein. EC 1.14.14.89, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Akashi, T., Aoki, T. and Ayabe, S.-I.
    CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase.
    Biochem. Biophys. Res. Commun. 251: 67-70 (1998). [PMID: 9790908]

[EC 1.14.14.90 created 2005 as EC 1.14.13.89, transferred 2018 to EC 1.14.14.90]