EC 1.14.14.73 - Albendazole monooxygenase (sufoxide-forming)

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IntEnz Enzyme Nomenclature
EC 1.14.14.73

Names

Accepted name:
albendazole monooxygenase (sufoxide-forming)
Other names:
albendazole sulfoxidase [ambiguous]
albendazole hydroxylase [ambiguous]
CYP3A4
CYP2J2
CYP1A2
Systematic name:
albendazole,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (sufoxide-forming)

Reactions

Comments:

This is one of the activities carried out by some microsomal cytochrome P450 monooxygenases. A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32, albendazole monooxygenase (flavin-containing)), but it is estimated that cytochrome P450s are responsible for 70% of the activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Moroni, P., Buronfosse, T., Longin-Sauvageon, C., Delatour, P., Benoit, E.
    Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes.
    Drug Metab. Dispos. 23: 160-165 (1995). [PMID: 7736906]
  2. Rawden, H. C., Kokwaro, G. O., Ward, S. A., Edwards, G.
    Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
    Br J Clin Pharmacol 49: 313-322 (2000). [PMID: 10759686]
  3. Asteinza, J., Camacho-Carranza, R., Reyes-Reyes, R. E., Dorado-Gonzalez, V., Espinosa-Aguirre, J. J.
    Induction of cytochrome P450 enzymes by albendazole treatment in the rat.
    Environ. Toxicol. Pharmacol. 9: 31-37 (2000). [PMID: 11137466]
  4. Lee, C. A., Neul, D., Clouser-Roche, A., Dalvie, D., Wester, M. R., Jiang, Y., Jones, J. P., Freiwald, S., Zientek, M., Totah, R. A.
    Identification of novel substrates for human cytochrome P450 2J2.
    Drug Metab. Dispos. 38: 347-356 (2010). [PMID: 19923256]
  5. Wu, Z., Lee, D., Joo, J., Shin, J. H., Kang, W., Oh, S., Lee, D. Y., Lee, S. J., Yea, S. S., Lee, H. S., Lee, T., Liu, K. H.
    CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.
    Antimicrob. Agents Chemother. 57: 5448-5456 (2013). [PMID: 23959307]

[EC 1.14.14.73 created 2018]